Testosterone Tied to Sustained Weight Loss in Men With Hypogonadism and Obesity
SAN DIEGO — Long-term testosterone therapy was associated with sustained reductions in weight for men with hypogonadism and class III obesity, a researcher reported. In registry data on 76 patients, those who opted to receive testosterone undecanoate experienced a 26% reduction in their body mass index (BMI) over close to a decade of follow-up, reported […]
Treatment De-Escalation Shows Promise in Testicular Cancer
A reduced dose of chemotherapy and involved node radiotherapy (INRT) may be viable for patients with stage IIA or IIB seminoma of the testis, results from a phase II study suggested. In a group of 116 patients, a single-dose of carboplatin along with de-escalated INRT yielded a 3-year progression-free survival (PFS) rate of 93.7% (90% […]
Obesity drug helps teens lose weight, study finds
A drug called semaglutide, which is approved for adults with obesity or overweight, also helps adolescents shed pounds and have healthier hearts, according to a new study published today in the New England Journal of Medicine and presented at Obesity Week 2022. In an international phase 3a clinical trial, adolescents with obesity who received once-weekly […]
Early Promise With Fluoxetine for Refractory Nocturnal Enuresis in Children
Children with refractory primary monosymptomatic nocturnal enuresis (PMNE) obtained significant short-term symptom relief with the selective serotonin reuptake inhibitor (SSRI) fluoxetine, a small placebo-controlled trial showed. Two-thirds of patients in the fluoxetine arm had more than a 50% reduction in wet nights by 4 weeks, as compared with 16.7% of the placebo group. By 12 […]
Good, and Safe, Results Tied to Oral Testosterone in Men With Deficiency
MIAMI — Oral testosterone replacement therapy (TRT) seemed safe and effective in men with testosterone deficiency, according to a meta-analysis. Among nine studies that looked at changes in serum total testosterone, only men with testosterone deficiency who took an oral agent — predominantly testosterone undecanoate — saw a significant increase in total testosterone, with a […]
This Popular, Painful Massage Goes INSIDE Your Mouth. But Does It Work?
If you’ve ever had a facial, you’re probably familiar with the aesthetician massaging the outside of your cheeks. But have you ever had them massage the inside of your cheeks? It sounds strange, but that’s what a buccal facial massage is all about. While these massages have been around for some time, social media and […]
Vaginal Testosterone Shows Benefit in Postmenopausal Women
MIAMI — Postmenopausal women with frequent urinary tract infections benefited from vaginal testosterone (VT) cream, interim data from the randomized, double-blind placebo-controlled PIVoT trial suggested. Women in the VT group saw improvements in vaginal health and sexual function scores at 9 months compared with placebo, although the placebo group’s sexual function scores also improved, reported […]
No Excess Pregnancy, Infant Risks With Ocrelizumab for MS
Women with multiple sclerosis (MS) who were treated with ocrelizumab (Ocrevus) had no increased risk of adverse pregnancy and infant outcomes, prospective data showed. Cumulative data did not suggest an increased risk of preterm birth, major congenital anomalies, or other adverse outcomes with ocrelizumab in utero exposure and were consistent with epidemiological data, reported Celia […]
State Insurance Mandates Don’t Improve Racial Disparities in ART Live Births
ANAHEIM, Calif. — Insurance mandates for fertility treatment with donor oocytes may improve overall live birth rates, but the current policies fail to reduce racial disparities in assisted reproductive treatment (ART), according to a retrospective study. Overall, state insurance requirements for coverage of donor oocytes were linked to a 10% increase in the odds of […]
Start HIV Antiretroviral Therapy ASAP, Experts Urge
WASHINGTON — Early initiation of antiretroviral therapy (ART) in patients with HIV can lead to better outcomes, especially for those ages 35 and younger, a follow-up analysis of the START trial showed. For patients who had deferred ART until their CD4 counts were below 350 cells/mm3, there was a 21% higher risk of death or […]