FDA Broadens Options for Relapsed/Refractory Multiple Myeloma With Teclistamab
Treatment options for relapsed/refractory multiple myeloma continue to expand with FDA’s accelerated approval of teclistamab (Tecvayli). The approval stipulates use of the bispecific antibody in adults who have received at least four prior therapies, including an immunomodulator, a proteasome inhibitor, and an anti-CD38 antibody (triple-class refractory disease). The first approved drug of its kind, teclistamab […]
Activity ‘snacks’ following meals may help maintain muscle mass
Interrupting prolonged sitting with periodic activity “snacks” may help maintain muscle mass and quality, according to a new study by researchers at the University of Toronto. Daniel Moore, an associate professor of muscle physiology at the Faculty of Kinesiology & Physical Eduction (KPE) who led the study, found that short bouts of activity, such as […]
High-Dose-Rate Brachytherapy Boost in Prostate Cancer Improves QOL
SAN ANTONIO — Men with intermediate- and high-risk prostate cancer treated with external-beam pelvic radiotherapy (EBRT) had better quality of life (QOL) outcomes when the combined prostate brachytherapy boost had a high dose rate (HDR), according to research presented here. In a randomized phase III trial comparing health-related QOL outcomes after either low dose rate […]
Nutrition Group Has Close Ties to Food, Pharma Companies
A large U.S. nutrition group and its foundation have a “symbiotic” relationship with the food and pharmaceutical industries, according to public health researchers. In an analysis of documents obtained via a freedom of information request, key leadership for the Academy of Nutrition and Dietetics (AND) hold important positions in multinational food and agribusiness companies, according […]
Extra Hep B Vaccine Dose Exceeds Expectations for People With HIV
WASHINGTON — Three doses of hepatitis B vaccine with a cytosine phosphoguanine adjuvant (HepB-CpG; Heplisav-B) notched a perfect mark when it came to seroprotection for people with HIV who had never before been vaccinated against the hepatitis B virus (HBV), early results of a phase III trial showed. At 28 weeks, the three doses yielded […]
APRNs: Get Your X-Waiver to Help in the Opioid Abuse Public Health Crisis
LONG BEACH, Calif. — Healthcare providers with advanced practice credentials should consider getting federal waivers to prescribe buprenorphine in the ongoing fight against the opioid epidemic, experts said. “There are a whole slew of benefits for patients who end up on medications for their opioid use disorder [OUD]. These medications do save lives,” said Amanda […]
Novel Siderophore Cephalosporin Nets Promising Results in Tough-to-Treat CRAB
WASHINGTON – Cefiderocol (Fetroja) may be a viable targeted-therapy option in critically ill patients with carbapenem-resistant Acinetobacter baumannii infections (CRAB), according to the ongoing PROVE trial. In the real-world setting, patients with CRAB often had multiple comorbidities, including severe burns, which complicates therapy, explained Stephen Marcella, MD, of Shionogi in Florham Park, New Jersey. He […]
Post-Op Pain Control More Challenging for Cannabis Users
NEW ORLEANS — Cannabis users reported somewhat worse postoperative pain compared with people who did not use cannabis before surgery, according to a large observational study. The difference was modest, however, as cannabis users had time-weighted average pain scores after surgery that were 0.58 higher on a scale from 0 to 10 (P<0.001), and they […]
Engaging in Healthcare May Close Longevity Gap Between Black and White Men With HIV
WASHINGTON — For men who have sex with men and are living with HIV, adopting strategies that would further engage Black men with the healthcare system could potentially close the gap in longevity between Black and white men, researchers suggested here. Using the framework of the HIV Care Continuum, simulation modeling showed that engagement with […]
How One Children’s Hospital Is Confronting a ‘Sick Season’ Surge
Children have been presenting in large numbers and with more severe viral illnesses than typically seen, physicians at Children’s Hospital of Philadelphia (CHOP) said. The CHOP healthcare system, which includes two hospitals and more than 600 beds, is still grappling with a high volume of pediatric patients with viral infections, including respiratory syncytial virus (RSV), […]