Landmark Trial Produces New First-Line Standard for Advanced Bladder Cancer
MADRID — Chemotherapy’s generation-long dominance in first-line advanced urothelial cancer ended with a resounding victory for the antibody-drug conjugate (ADC) enfortumab vedotin (Padcev) plus pembrolizumab (Keytruda) in an international randomized trial. Overall survival (OS) and progression-free survival (PFS) doubled with enfortumab-pembrolizumab (EV-P) at 12.5 and 31.5 months versus 6.3 and 16.1 months with platinum-containing chemotherapy. […]
Tebentafusp’s OS Benefit in Uveal Melanoma Holds Up at 3 Years
MADRID — The significant survival benefit with the bispecific T-cell receptor therapy tebentafusp (Kimmtrak) held up at 3 years for selected patients with previously untreated metastatic uveal melanoma, updated results of a phase III trial demonstrated. In HLA-A*02:01-positive patients, landmark analyses showed improved overall survival (OS) at 1, 2, and 3 years with tebentafusp versus […]
ART Embryo Transfers to Gestational Carriers Increased Chances of Pregnancy
NEW ORLEANS — Assisted reproductive technology (ART) cycles with an embryo transfer to a gestational carrier increased the likelihood of pregnancy and live birth, an analysis of national data from 2014 to 2020 showed. In over 1 million ART cycles with an embryo transfer, those with a gestational carrier were more likely to result in […]
Adults with ADHD are at increased risk for developing dementia
Adults with attention-deficit/hyperactivity disorder (ADHD) are nearly three times more likely to develop dementia than adults without ADHD, according to a Rutgers study. The study, coauthored by Michal Schnaider Beeri, director of the Herbert and Jacqueline Krieger Klein Alzheimer’s Research Center at Rutgers Brain Health Institute (BHI) was published in JAMA Network Open. It followed […]
The Case for a Yearly COVID Booster Shot
BOSTON — A yearly booster with an mRNA-based COVID vaccine may provide the best protection against catching the pandemic disease, a new analysis of the phase III COVE trial suggested. “Interestingly, we found that the longer duration between boosting actually provides better protection against COVID-19,” Dean Follmann, PhD, of the National Institute of Allergy and […]
Study Validates Accuracy of PREDICT Prognostication Tool in Breast Cancer
The PREDICT prognostication tool was able to estimate overall survival (OS) with decent accuracy in a large independent U.S. dataset of breast cancer patients, researchers reported. From more than 700,000 patients in the National Cancer Database (NCDB), the free online tool estimated median and mean 5-year OS rates ranging from 83.3% to 84.4%, as compared […]
Jet lag disorder associated with shift work can lead to brain changes increasing appetite
Scientists have uncovered why night shift work is associated with changes in appetite in a new University of Bristol-led study. The findings, published in Communications Biology, could help the millions of people that work through the night and struggle with weight gain. Scientists from Bristol and the University of Occupational and Environmental Health in Japan, […]
HER3-Targeted Drug Active in Advanced/Metastatic Breast Cancer
An antibody-drug conjugate (ADC) targeting HER3 produced objective responses in as many as 43% of patients with advanced breast cancer, a prospective clinical trial showed. Responses to patritumab deruxtecan (HER3-DXd) occurred in the three major types of breast cancer, ranging from 22.6% in triple-negative breast cancer (TNBC) to 30.1% in hormone receptor (HR)-positive/HER2-negative breast cancer […]
Scientists says identifying some foods as addictive could shift attitudes, stimulate research
Researchers from the United States, Brazil, and Spain, including scientists with the Fralin Biomedical Research Institute at VTC, published an analysis in a special edition of the British Medical Journal with a timely and controversial recommendation: It’s time for an international shift in the way we think about ultra-processed food. “There is converging and consistent […]
Depressive Symptoms Tied to Higher Mortality Risk in U.S. Adults
Depressive symptoms were associated with a higher risk for all-cause and cardiovascular disease (CVD) mortality, according to a nationally representative prospective cohort study. Of nearly 23,700 U.S. adults, mild depressive symptoms were associated with a significantly higher risk of all-cause mortality compared with no symptoms (HR 1.35, 95% CI 1.07-1.72), as were moderate to severe […]