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Side Benefit of Botulinum Toxin A? Reduced IOP in Hemifacial Spasm

Injection with botulinum toxin A (BTX-A) for hemifacial spasm (HFS) may have an additional benefit: decreasing unilateral eyelid spasms and intraocular pressure (IOP), according to a small Brazilian study. Mean IOP was 11 ± 3.42 mm Hg before treatment in the affected eye and 9 ± 2.98 mm Hg in the contralateral eye (P=0.012). Post-BTX-A […]

Intermittent fasting is safe, effective for those with Type 2 diabetes, study suggests

Time-restricted eating, also known as intermittent fasting, can help people with Type 2 diabetes lose weight and control their blood sugar levels, according to a new study published in JAMA Network Open from researchers at the University of Illinois Chicago. Participants who ate only during an eight-hour window between noon and 8 p.m. each day […]

Misoprostol Alone in Self-Managed Abortion Is Highly Effective

Use of misoprostol alone was shown to be effective in self-managed abortion, with minimal side effects, according to a prospective observational cohort study of callers to safe abortion hotlines in Nigeria, Argentina, and Southeast Asia. In the cohort of 637 callers who used a misoprostol-alone regimen, 98.1% had a complete abortion without procedural intervention at […]

Tinnitus Worsens for Vaccine Scientist Who Points to Onset After COVID Vax

In March of last year, Gregory Poland, MD, was grappling with what he described as unrelenting symptoms of tinnitus that he developed shortly after receiving his second dose of an mRNA COVID-19 vaccine in early 2021. About a year-and-a-half later, after his first COVID infection, Poland told MedPage Today that his tinnitus has worsened. Indeed, […]

Randomized Trial Backs HIF-2a Inhibition in Advanced RCC

MADRID — Treatment with the hypoxia-inducible factor 2α (HIF-2α) inhibitor belzutifan (Welireg) in advanced, heavily pretreated kidney cancer led to superior outcomes when compared with an older kinase inhibitor, a phase III trial demonstrated. Final progression-free survival (PFS) analysis showed a 26% reduction in disease progression or death with belzutifan versus everolimus (Afinitor), despite an […]

Convalescent Plasma Improves Survival in COVID Patients with ARDS, New Trial Shows

Convalescent plasma reduced mortality in COVID-19 patients with acute respiratory distress syndrome (ARDS) when provided within 5 days of invasive mechanical ventilation, the randomized open-label CONFIDENT trial showed. Mortality at 28 days was 35.4% among patients who received donated convalescent plasma with at least 1:160 neutralizing antibody titer, compared with 45% in patients who received […]

RET Inhibitor Posts Frontline Wins in Medullary Thyroid Cancer, NSCLC

MADRID — First-line treatment with the RET inhibitor selpercatinib (Retevmo) achieved superior outcomes in both medullary thyroid cancer (MTC) and advanced non-small cell lung cancer (NSCLC), according to results from two phase III trials presented here. In the LIBRETTO-531 trial, selpercatinib resulted in superior progression-free survival (PFS) and treatment failure-free survival (TFFS) compared with the […]

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