Bladder-Sparing Neoadjuvant Protocol Gets High Marks for MIBC
More than 40% of patients with muscle-invasive bladder cancer (MIBC) avoided immediate cystectomy after achieving a clinical complete response (cCR) with a chemoimmunotherapy combination, a prospective study showed. Overall, 33 of 76 patients with MIBC achieved a cCR by stringently defined criteria following transurethral resection of bladder tumor (TURBT) and treatment with gemcitabine, cisplatin, and […]
Strong link between ADHD and car crashes in older adult drivers
In a study on the prevalence of attention-deficit/hyperactivity disorder (ADHD) and its association with crash risk among older adult drivers, researchers at Columbia University Mailman School of Public Health found that older adult drivers with ADHD are at a significantly elevated crash risk compared with their counterparts without ADHD. Outcomes included hard- braking events, and […]
ADHD and Car Crashes; New Guidance on Stimulant Use Disorder Tx; KarXT Heads to FDA
Older adults with attention deficit-hyperactivity disorder (ADHD) had a significantly higher incidence of car crashes. (JAMA Network Open) Meanwhile, the estimated prevalence of ADHD in kids 4 years and up held steady — between 10.08% to 10.47% — from 2017 to 2022, according to nationally representative data. (JAMA Network Open) The FDA released new draft […]
Mortality Risk From Damaged Bronchi Extends to People Without COPD
Bronchiectasis was associated with an increased mortality risk in current and former smokers even if they did not meet the spirometric criteria for chronic obstructive pulmonary disease (COPD), an observational study found. Compared with patients without suspected bronchiectasis, the 10-year mortality risk was greater among patients who had suspected bronchiectasis — evidenced by CT and […]
Menopausal Women With Obesity Endure Worse Symptoms, Less HT Relief
PHILADELPHIA — Women with obesity may experience worse menopausal symptoms and see less relief from hormone therapy (HT), according to a pilot study. When compared with women without obesity, those with a BMI of 30 or greater were significantly more likely to report menopause-related vasomotor symptoms like hot flashes and night sweats (74% vs 45%, […]
New Insight Into Hyperglycemia Risk With PI3K Inhibitor for Breast Cancer
Severe hyperglycemia has emerged as a common side effect among patients with PIK3CA-mutated breast cancer treated with the PI3K inhibitor alpelisib (Piqray), especially patients treated outside a clinical trial, a retrospective study showed. Overall, 61.5% of 247 patients developed any degree of hyperglycemia, which reached grade 3/4 severity in 29%. Any grade of hyperglycemia occurred […]
Cancer Risk in NAFLD Higher With Early Disease Onset
The risk for cancer in patients with nonalcoholic fatty liver disease (NAFLD) was highest among those with early-onset disease and declined at later ages of diagnosis, a matched cohort study found. Examining more than 60,000 participants from a prospective Chinese dataset revealed that the increased risk of malignancy with NAFLD was highest among patients diagnosed […]
SBRT Added to Standard Tx Boosts Outcomes in Oligometastatic Prostate Cancer
Combining stereotactic body radiation therapy (SBRT) with standard systemic therapy yielded significant increases in the rates of biochemical response and progression-free survival (PFS) in patients with oligometastatic castrate-resistant prostate cancer (CRPC), the phase II randomized ARTO trial showed. In a cohort of 157 patients at 6 months after the start of treatment, biochemical response was […]
Study Confirms Better Survival for HPV-Positive Cervical Cancer
Cervical cancer associated with detectable human papillomavirus (HPV+) RNA or DNA had significantly better outcomes, including survival, a large meta-analysis of published studies showed. Patients who tested positive for HPV had a 62% improvement in disease-free survival (DFS), 44% improvement in cancer-specific survival (CSS), and 41% improvement in overall survival (OS), as compared with patients […]
What Is the ‘Carrot Tan’ Trending on Social Media? A Dermatologist Weighs In
Welcome to Culture Clinic, MedPage Today’s collaboration with Northwell Health to offer a healthcare professional’s take on the latest viral medical topics. Social media’s latest aesthetic trend? Overloading on carrots to get a quick tan. Amid the craze, MedPage Today spoke with Silvija P. Gottesman, MD, a dermatologist at Northwell Health’s North Shore University Hospital […]