Upfront Systemic Therapy, Deferred Surgery Pass Muster in Advanced Kidney Cancer
CHICAGO — Perioperative immunotherapy for advanced kidney cancer did not adversely affect outcomes with cytoreductive nephrectomy and appeared to have several beneficial effects, a small multicenter study showed. Primary immunotherapy significantly reduced median tumor size and thrombus length and improved tumor thrombus level and mean RENAL score. Immunotherapy led to pathologic downstaging in 25 of […]
Sodium Thiosulphate Not Much Help for Calciphylaxis in CKD
Intravenous sodium thiosulphate flopped for treating calciphylaxis in people with chronic kidney disease (CKD), researchers reported. In a systematic review and meta-analysis, there was no significant difference in skin lesion improvement seen across 12 studies of patients treated with and without IV sodium thiosulphate (risk ratio 1.23, 95% CI 0.85-1.78), found Wen Wen, MD, MMSc, […]
Daily Thiazide No Help in Preventing Recurrent Kidney Stones
A common diuretic wasn’t much help for staving off recurrent kidney stones, the NOSTONE trial showed. Over a median follow-up of 2.9 years, symptomatic or radiologic recurrence of kidney stones occurred in 59% of patients who received hydrochlorothiazide (12.5 mg once daily) and 59% of those assigned placebo (rate ratio [RR] 1.33, 95% CI 0.92-1.93), […]
Mixed Results With Alerts for AKI-Related Medications in Hospital
While medication-targeted acute kidney injury (AKI) alerts led to certain kidney-affecting medications being stopped, the overall clinical impact was limited, a researcher reported. The open-label, randomized trial included over 5,000 patients hospitalized for AKI with an active order for one of the medication of interest (MOIs) classes that were selected as being possibly nephrotoxic — […]
Is it really healthy to restrict protein intake for kidney transplant recipients? Study suggests that sufficient protein intake is necessary to prevent sarcopenia after kidney transplantation
Conventional wisdom holds that low protein intake is essential for kidney disease patients. However, scientists from Osaka Metropolitan University demonstrated that it might not always be the case with their recent study on the relationship between protein intake and skeletal muscle mass in kidney transplant recipients. Their findings were published in Clinical Nutrition. Chronic kidney […]
Opinion | Medical Education Has ‘Gone Woke’ — That’s a Good Thing
A Black woman whose kidneys only function at 15% of normal wishes to be evaluated for a kidney transplant. Although this is very reasonable, before 2021, many physicians would have said, “I’m sorry, but your kidney function is not bad enough to be referred for a transplant.” This is because the kidney function calculator used […]
New Insights Into Link Between Kidney Stones, Urinary Tract Infection
Kidney stone disease (KSD) and urinary tract infection (UTI) often coexist, and stone removal may reduce the risk of recurrent UTI, authors of a systematic review concluded. The review showed a bidirectional nature of the relationship between KSD and UTI, as stone formers had a high prevalence of UTI and patients evaluated for UTI had […]
Removing Small Asymptomatic Kidney Stones Significantly Reduces Recurrence
Removing small, asymptomatic kidney stones during endoscopic removal of ureteral or contralateral stones significantly prolonged the time to relapse as compared with leaving the asymptomatic stones behind, a randomized trial showed. The time to relapse averaged about 4.5 years with removal of asymptomatic stones versus about 2.5 years without (P<0.001). The difference represented an 82% […]
Aldosterone Linked to Kidney Failure Risk, Irrespective of Diabetes
Higher serum aldosterone levels were linked to a greater risk of kidney failure in chronic kidney disease (CKD), both for those with and without diabetes, a study showed. Every doubling in aldosterone level was associated with 11% (95% CI 1.04-1.18) greater risk of progression of CKD to end-stage kidney disease or halving of estimated glomerular […]
Had a Kidney Stone? This Diet May Help Prevent Another – MedicineNet Health News
Latest Digestion News By Cara Murez HealthDay Reporter WEDNESDAY, Aug. 3, 2022 Anyone who has ever had a kidney stone never wants a repeat of the blinding pain that comes when it passes. Now, a new study maps out a diet that can help guard against that. The cornerstones of that diet include eating plenty […]