Diets higher in calcium and potassium may help prevent recurrent symptomatic kidney stones
Kidney stones can cause not only excruciating pain but also are associated with chronic kidney disease, osteoporosis and cardiovascular disease. If you’ve experienced a kidney stone once, you have a 30% chance of having another kidney stone within five years. Changes in diet are often prescribed to prevent recurrent symptomatic kidney stones. However, little research […]
Cytomegalovirus (CMV) Infection: Symptoms & Treatment
Things to know about cytomegalovirus (CMV) infection Picture of owl eye inclusion bodies in kidney cells of an individual with cytomegalovirus infection; SOURCE: CDC/Dr. Haraszti CMV is a common virus in the same family as herpesvirus, and it can infect anyone. CMV spreads by direct contact with body fluids, such as saliva, blood, urine, semen, […]
Novel Drug Cuts Proteinuria in APOL1-Mediated Kidney Disease
An investigative treatment targeting APOL1 activity significantly improved proteinuria APOL1-mediated kidney disease (AMKD), a proof-of-concept phase IIa study found. In a single-arm, open-label study, treatment with oral VX-147 — a small molecule acting as an APOL1 function inhibitor — significantly reduced urine protein to creatinine ratio (UPCR) by 47.6% (95% CI -60 to -31.3%) by […]
Even With CKD, Patiromer Helped Heart Failure Patients Keep Hyperkalemia at Bay
Regardless of chronic kidney disease (CKD) stage, the potassium-binding agent patiromer (Veltassa) improved serum potassium levels in patients with heart failure, according to a prespecified CKD subanalysis from the DIAMOND trial. In a subgroup of patients with heart failure with reduced ejection fraction plus CKD, and hyperkalemia due to renin-angiotensin-aldosterone system inhibitors (RAASi), patiromer significantly […]
Complex three-dimensional kidney tissue generated in the lab from the scratch
A research team based in Kumamoto University (Japan) has created complex 3D kidney tissue in the lab solely from cultured mouse embryonic stem (ES) cells. These organoids could lead the way to better kidney research and, eventually, artificial kidneys for human transplant. By focusing on an often-overlooked tissue type of organoid generation research, a type […]
High protein diet may harm polar bears
A high protein diet appears linked to kidney disease and shortened lifespans for captive polar bears, a relationship similarly suspected in humans, according to a review led by Washington State University wildlife biologist Charlie Robbins. The paper, published in Zoo Biology, takes careful look at what zoos have fed polar bears revealing they mostly offered […]
Did HIV Status Affect Transplant Patients’ Long-Term Outcomes?
Patient survival in liver transplant recipients and graft survival in kidney transplant recipients was comparable among patients living with and without HIV, even 15 years later, researchers found in a retrospective study. For liver transplant recipients, patient survival at 15 years among those living with HIV was 70% (95% CI 60.6-80.8%) compared to 75.7% (95% […]
Blood metabolites associated with coffee consumption may affect kidney disease risk
Food and beverages may have important effects on kidney health, but the potential biological mechanisms involved are often unclear. New research in CJASN identifies several metabolites in the blood whose levels are altered by coffee consumption and may affect the risk of developing chronic kidney disease (CKD). When Casey M. Rebholz, PhD, MS, MNSP, MPH […]
Finerenone improves outcomes in patients with mild-to-moderate kidney disease and diabetes
Finerenone reduces the risk of cardiovascular morbidity and mortality in patients with mild-to-moderate kidney disease and type 2 diabetes. That’s the finding of late breaking research presented in a Hot Line session today at ESC Congress 20211 and published in the New England Journal of Medicine2. Diabetic kidney disease develops in approximately 40% of patients […]
Finerenone OK’d for Slowing Kidney Disease in T2D
The FDA approved the anti-mineralocorticoid agent finerenone (Kerendia) for slowing the progression of chronic kidney disease in type 2 diabetes patients, the agency announced on Friday. The first non-steroidal, selective mineralocorticoid receptor antagonist was approved to reduce the risk of sustained estimated glomerular filtration rate (eGFR) decline, end-stage kidney disease, cardiovascular death, non-fatal myocardial infarction, […]