Depressive Symptoms Tied to Higher Mortality Risk in U.S. Adults
Depressive symptoms were associated with a higher risk for all-cause and cardiovascular disease (CVD) mortality, according to a nationally representative prospective cohort study. Of nearly 23,700 U.S. adults, mild depressive symptoms were associated with a significantly higher risk of all-cause mortality compared with no symptoms (HR 1.35, 95% CI 1.07-1.72), as were moderate to severe […]
CPAP Turns in Mixed Results for Patients With Diabetic Eye Disease
Long-term use of continuous positive airway pressure (CPAP) slowed the progression of eye disease in sleep apnea patients with non-proliferative diabetic retinopathy, a small randomized study showed, but patients who adhered to the intervention ended up with more retinal microhemorrhages. In the single-center trial, the group assigned to a year of CPAP atop usual care […]
Cancer Risk in NAFLD Higher With Early Disease Onset
The risk for cancer in patients with nonalcoholic fatty liver disease (NAFLD) was highest among those with early-onset disease and declined at later ages of diagnosis, a matched cohort study found. Examining more than 60,000 participants from a prospective Chinese dataset revealed that the increased risk of malignancy with NAFLD was highest among patients diagnosed […]
Acetazolamide May Help COPD Patients Reach New Heights
Acetazolamide may prevent some patients with chronic obstructive pulmonary disease (COPD) from suffering altitude-related adverse health effects (ARAHE) when traveling, a randomized controlled trial showed. In patients with moderate to severe COPD traveling to and staying for 2 days at 3,100 m, ARAHE occurred in 50% of those taking acetazolamide compared with 74% of those […]
Prescription for fruits, vegetables linked to better heart health, food security
People at increased risk for cardiovascular disease who participated in produce prescription programs increased their consumption of fruits and vegetables, which was associated with improved body mass index (BMI), blood sugar and blood pressure levels, as well as a decrease in food insecurity. This new research was published today in Circulation: Cardiovascular Quality and Outcomes, […]
Retinal Changes Emerge Years Before Parkinson’s Disease
People with Parkinson’s disease had retinal changes that could be seen with optical coherence tomography (OCT) years before diagnosis, cross-sectional data suggested. Both incident and prevalent Parkinson’s disease were associated with reduced ganglion cell-inner plexiform layer (GCIPL) and inner nuclear layer (INL) thicknesses, reported Siegfried Karl Wagner, MSc, MD, of University College London in England, […]
Few Early Alzheimer’s Patients Qualify for Lecanemab
Few people with early Alzheimer’s disease met eligibility criteria for the new anti-amyloid monoclonal antibody treatments lecanemab (Leqembi) and aducanumab (Aduhelm), cross-sectional data from the Mayo Clinic Study of Aging showed. Of 237 people with mild cognitive impairment or mild dementia and increased brain amyloid on PET, clinical trial inclusion and exclusion criteria narrowed the […]
The Biggest Early Warning Signs Of Bacterial Meningitis
Edwin Tan via Getty Images Approximately 21% of meningococcal disease cases affect young people ages 11 to 24. Bacterial meningitis, a potentially fatal infection that causes the protective membranes of the brain and spine to become inflamed, is relatively rare. According to the National Meningitis Association, about “600 – 1,000 people contract meningococcal disease in […]
Pegcetacoplan-Related Eye Inflammation: The Search Is on for Answers
SEATTLE — Reports of unexpected panuveitis and retinal occlusive vascular disease associated with pegcetacoplan (Syfovre) treatment has triggered a search for answers by ophthalmologists and the drug’s manufacturer. Since July 3, the American Society of Retina Specialists (ASRS) Research and Safety in Therapeutics (ReST) Committee has learned of seven cases of retinal inflammation and vascular […]
NAFLD and T2DM Bodes Higher Risk of Liver Decompensation, Cancer
Patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes may be at significantly higher risk of hepatic decompensation and liver cancer, researchers reported. In a meta-analysis of six studies that included 1,737 patients with NAFLD followed for approximately 3 years, those with diabetes had twice the risk for developing hepatic decompensation (HR 2.15, […]