Moderna’s mRNA RSV Vaccine Effective in Older Adults
Moderna’s mRNA-based RSV vaccine was effective at preventing RSV-associated lower respiratory tract disease in adults ages 60 and older, according to results of the randomized ConquerRSV trial. The mRNA-1345 vaccine was 83.7% effective (95.88% CI 66%-92.2%) in preventing RSV-associated lower respiratory tract disease with at least two signs or symptoms, and similarly effective (82.4%) against […]
MRD Tied to Allo-Transplant Benefit in NPM1-Mutated Acute Myeloid Leukemia
SAN DIEGO — Measurable residual disease (MRD) after induction therapy can guide the use of allogeneic transplant in patients with NPM1-mutated acute myeloid leukemia (AML) in first remission, regardless of whether FLT3 internal tandem duplication (ITD) mutations are present as well, according to an analysis of two randomized trials. Of more than 700 patients in […]
Clinical trial demonstrates that the ketogenic diet is effective at controlling polycystic kidney disease
It’s official: The ketogenic diet proved to be effective at controlling polycystic kidney disease (PKD) in the first randomized controlled clinical trial of ketogenic metabolic therapy for PKD. “I’m really happy about these clinical trial results,” said UC Santa Barbara biologist Thomas Weimbs, whose lab was part of an international collaboration to investigate the effect […]
Coronary Heart Disease by Age 45 Linked With Subsequent Dementia
Younger onset age of coronary heart disease was tied to higher risks of incident all-cause dementia, Alzheimer’s disease, and vascular dementia, a large prospective cohort study in Great Britain showed. Each 10-year decrease in coronary heart disease onset age was associated with a 25% increased risk of all-cause dementia, a 29% increased risk of Alzheimer’s […]
Methotrexate Tied to Greater Risks for Older Patients With CKD
Older patients with chronic kidney disease (CKD) had greater risks for serious adverse events when starting on low-dose methotrexate rather than hydroxychloroquine, a propensity score-matched analysis found. About 60% of the cohort’s new prescription came from a rheumatologist. Within 90 days of starting either treatment, the risk for the composite outcome — a hospital visit […]
Mahvash Disease Case Resolved With Liver Transplantation
A woman with Mahvash disease presented with portal hypertension that necessitated liver transplantation; the liver complications observed in this case report distinguish it from what’s more typically seen in patients with this condition. The 27-year-old woman presented with mildly elevated aminotransferase levels and chronic pancreatitis after having experienced three episodes of hematemesis. Although her imaging […]
Mahvash Disease Case Resolved With Liver Transplantation
A woman with Mahvash disease presented with portal hypertension that necessitated liver transplantation; the liver complications observed in this case report distinguish it from what’s more typically seen in patients with this condition. The 27-year-old woman presented with mildly elevated aminotransferase levels and chronic pancreatitis after having experienced three episodes of hematemesis. Although her imaging […]
Is red meat intake linked to inflammation?
Inflammation is a risk factor for many chronic diseases, including cardiovascular disease (CVD), and the impact of diet on inflammation is an area of growing scientific interest. In particular, recommendations to limit red meat consumption are often based, in part, on old studies suggesting that red meat negatively affects inflammation — yet more recent studies […]
Tropical Parasite May Be Endemic in Texas
A parasitic disease that can cause skin ulcers and is usually spread by the tiny sandfly may now be endemic to the U.S., preliminary findings from CDC researchers suggested. Genetic sequencing of 2,235 U.S. cutaneous leishmaniasis samples submitted from 2005 to 2019 confirmed the presence of a potentially distinct genotype of the Leishmania mexicana species […]
Flu And RSV Could Be On The Rise Nationwide
LOADINGERROR LOADING The Centers for Disease Control and Prevention reported on Friday that flu cases are low nationwide, but more could arise in the upcoming weeks. “Even these low levels will probably increase in the next couple of weeks,” said Alicia Budd, head of the CDC’s domestic influenza surveillance team, according to NBC News. Advertisement […]