Alzheimer’s Drug Wins Full FDA Approval
Lecanemab (Leqembi) became the first Alzheimer’s treatment targeted at the disease process to win full FDA approval, the agency announced today. “Today’s action is the first verification that a drug targeting the underlying disease process of Alzheimer’s disease has shown clinical benefit in this devastating disease,” said Teresa Buracchio, MD, acting director of the Office […]
Subclinical CVD Detected in Kids With Higher Arsenic Burden
Greater arsenic exposure was linked to children harboring subclinical cardiovascular disease (CVD) as early as age 9, based on data from Syracuse, New York. In this upstate community with a history of industrial waste, total arsenic level significantly correlated with carotid intima media thickness and concentric hypertrophy (the latter indicated by greater left ventricular mass […]
Cystic Renal Masses Often Harbor High-Grade Disease
Almost a fourth of renal cysts had pathologically high-grade disease, which did not have a correlation with growth rate or increase the risk with active surveillance (AS), according to a large retrospective review. Overall, 23% of 387 radiographically confirmed cystic lesions exhibited high-grade pathology. Nonetheless, the potentially more aggressive subset did not affect overall survival, […]
Americans With Heart Disease Less Likely to Use Wearable Devices
Fewer Americans with or at risk for cardiovascular disease (CVD) used a wearable health monitoring device than the general population, according to a nationally representative sample using 2019-2020 Health Information National Trends Survey (HINTS) data. Only 18% of adults with CVD and 26% of those at risk for CVD reported using a wearable device to […]
Alzheimer’s Progression Delayed by Rare Genetic Variant
The world’s second case of ascertained extreme resilience to autosomal dominant Alzheimer’s disease was reported, suggesting a new way Alzheimer’s progression might be delayed. A rare genetic variant of RELN, which encodes the signaling protein reelin, was associated with 20 years of resilience to autosomal dominant Alzheimer’s disease in a Colombian man, reported Diego Sepulveda-Falla, […]
Opinion | AI Offers Hope for Those With Alzheimer’s Disease
According to the CDC, as of 2020, approximately 5.8 million people in the U.S. were living with Alzheimer’s disease. The prevalence of this disease is expected to continue to rise as the population ages. The number of people living with the disease is projected to grow three-fold, to 14 million, by 2060. While there is […]
Parkinson’s Biomarker Shows High Accuracy
An alpha-synuclein seed amplification assay (SAA) accurately detected Parkinson’s disease in cerebrospinal fluid (CSF) and identified people with early, non-motor symptoms prior to diagnosis, cross-sectional data from the Parkinson’s Progression Markers Initiative (PPMI) showed. Sensitivity for Parkinson’s disease overall was 87.7% and specificity for healthy controls was 96.3%, reported Andrew Siderowf, MD, of the University […]
Researchers leverage cell self-destruction to treat brain tumors
Glioblastoma is the most common type of brain tumor in adults. The disease is 100% fatal and there are no cures, making it the most aggressive type of cancer. Such a poor prognosis has motivated researchers and neurosurgeons to understand the biology of tumors with the goal of creating better therapies. Dominique Higgins, MD, PhD, […]
CDC Alerts Docs to Watch for Potential Imported Marburg Cases
While there have been no confirmed cases of Marburg virus disease (MVD) outside Equatorial Guinea and Tanzania, clinicians and public health experts should be aware of the potential for imported cases, the CDC said. In a Health Alert Network advisory, the agency said that it is important for clinicians to assess patients for the possibility […]
People with obesity due to genetic predisposition have lower risk of cardiovascular disease
The risk of developing cardiovascular disease is lower in people with obesity who have a genetic predisposition for high BMI than people with obesity influenced mainly by environmental factors such as lifestyle, researchers from Karolinska Institutet report in eClinicalMedicine. There has been a global increase in the incidence of overweight and obesity over the past […]