Clinical Challenges: Sequencing in Metastatic TNBC
As new treatment options continue to emerge for triple-negative breast cancer (TNBC), sequencing of therapy promises to get ever more complicated. TNBC had been estimated to account for about 15% of all breast cancer diagnoses, but that proportion shrank with the new HER2-low designation, which accounts for approximately one-third of patients diagnosed with TNBC. An […]
Clinical Challenges: Test Your Knowledge on New Breast Cancer Treatments
The number of available treatment options for patients newly diagnosed with breast cancer continues to grow. The following three-question quiz will test one aspect from each article in our “Clinical Challenges” series on advanced breast cancer, which covered managing adverse effects of novel therapies and sequencing of treatments in metastatic HER2-positive breast cancer and metastatic […]
Obesity linked to neurodegeneration through insulin resistance
Researchers led by Mroj Alassaf at the Fred Hutchinson Cancer Research Center in the United States have discovered a link between obesity and neurodegenerative disorders like Alzheimer’s disease. Using the common fruit fly, the research shows that a high-sugar diet — a hallmark of obesity — causes insulin resistance in the brain, which in turn […]
Opinion | Moving Beyond the ‘Angelina Jolie Effect’ to Address Cancer Disparities
Giri is a medical oncologist who specializes in clinical cancer genetics. *Patient’s name has been changed In room A is Tonya*, a 41-year-old African-American woman with metastatic breast cancer. In Room B is Joseph*, a 39-year-old Asian male with advanced colon cancer. As an oncologist who specializes in cancer genetics, I regularly see young patients […]
Opinion | Transitioning Cancer Survivors Away From Oncologic Care
Dinan is an associate professor of epidemiology and an oncology outcomes researcher. October was Breast Cancer Awareness month and the sudden influx of pink in our homes, on our televisions, in our workplaces, and in local businesses reminded us that we still lose far too many of our loved ones to cancer, not only in […]
ACS: Millions More Should Get Lung Cancer Screening
The American Cancer Society (ACS) widened the pool of past and current smokers eligible for lung cancer screening in its new guideline recommendations, potentially opening the door to 5 million more U.S. adults. Annual lung cancer screening with low‐dose CT is strongly recommended for asymptomatic patients ages 50 to 80 years who either currently smoke, […]
Radionuclide Therapy Tops AR-Pathway Inhibitor Switch for mCRPC
MADRID — Radiographic progression-free survival (rPFS) in metastatic castration-resistant prostate cancer (mCRPC) doubled when patients received a radionuclide ligand targeting prostate-specific membrane antigen (PSMA) instead of switching to another androgen receptor pathway inhibitor (ARPI), a randomized trial showed. In patients with prior progression on an ARPI, median rPFS increased from 5.9 months with another ARPI […]
Landmark Trial Produces New First-Line Standard for Advanced Bladder Cancer
MADRID — Chemotherapy’s generation-long dominance in first-line advanced urothelial cancer ended with a resounding victory for the antibody-drug conjugate (ADC) enfortumab vedotin (Padcev) plus pembrolizumab (Keytruda) in an international randomized trial. Overall survival (OS) and progression-free survival (PFS) doubled with enfortumab-pembrolizumab (EV-P) at 12.5 and 31.5 months versus 6.3 and 16.1 months with platinum-containing chemotherapy. […]
Bladder-Sparing Neoadjuvant Protocol Gets High Marks for MIBC
More than 40% of patients with muscle-invasive bladder cancer (MIBC) avoided immediate cystectomy after achieving a clinical complete response (cCR) with a chemoimmunotherapy combination, a prospective study showed. Overall, 33 of 76 patients with MIBC achieved a cCR by stringently defined criteria following transurethral resection of bladder tumor (TURBT) and treatment with gemcitabine, cisplatin, and […]
Report: Persistence of Gender Inequalities in Cancer Care, and a Call to Action
A global imbalance in “power dynamics” has negatively affected women’s access to cancer prevention, detection, and care, according to a report from a Lancet Commission. Cancer remains one of the top three causes of premature death among women in almost every country. Worldwide, 2.3 million women die prematurely of cancer each year. Of those deaths, […]