Two-Stage Screening Strategy for Ovarian Cancer Continues to Show Progress
A two-stage ovarian cancer screening strategy substantially improved early-stage detection among average-risk postmenopausal women, according to long-term follow-up from a large prospective study. Combining serial CA125 values and conditional referral for transvaginal sonography (TVS) led to a sensitivity of 74% for detection of ovarian and borderline cancers. Cancers detected by the Risk of Ovarian Cancer […]
FDA Clears AI-Powered Non-Invasive Skin Cancer Detector
The FDA cleared an artificial-intelligence (AI)-powered device designed to non-invasively detect skin cancer in the primary care setting, the agency announced on Tuesday. Developer DermaSensor said the device uses AI-powered spectroscopy technology to non-invasively evaluate cellular and subcellular characteristics of a lesion for any of the three common skin cancers — melanoma, basal cell carcinoma, […]
EGFR Inhibitors for Lung Cancer Tied to Increased Keratitis Risk
Patients with lung cancer treated with epidermal growth factor receptor (EGFR) inhibitors may have an increased risk of new-onset keratitis, a U.S. population-based cohort study showed. Over a 20-year period, 1.12% of patients who were treated with EGFR inhibitors developed new-onset keratitis compared with 0.74% of those who did not take these drugs (HR 1.520, […]
More Evidence Linking ADT for Prostate Cancer to Adverse Neurocognitive Effects
Men treated with androgen deprivation therapy (ADT) for prostate cancer had a significantly higher risk of dementia and other neurocognitive disorders, according to a meta-analysis of more than 2.5 million patients. The magnitude of excess risk ranged from 20% for dementia to 66% for depression. The risk of Alzheimer’s disease, vascular dementia, and Parkinson’s disease […]
How fruit bats got a sweet tooth without sour health
A high-sugar diet is bad news for humans, leading to diabetes, obesity and even cancer. Yet fruit bats survive and even thrive by eating up to twice their body weight in sugary fruit every day. Now, UC San Francisco scientists have discovered how fruit bats may have evolved to consume so much sugar, with potential […]
Financial Toxicity Among Single Mothers With Metastatic Breast Cancer
A study presented at the San Antonio Breast Cancer Symposium highlighted financial toxicity in underserved/underrepresented single mothers living with metastatic breast cancer, and how the situation can affect their physical, mental, and emotional health. In this exclusive MedPage Today video, Maryam Lustberg, MD, director of the Center for Breast Cancer at the Yale School of […]
Clinical Challenges: Test Your Knowledge of Breast Cancer
A MedPage Today Clinical Challenges series on breast cancer reviewed locoregional therapy for older patients, the management of invasive lobular cancer (ILC), and the treatment of advanced hormone receptor (HR)-positive disease post-CDK4/6 inhibition. The following is a three-question quiz to test your knowledge on each aspect of the series. Correct answers and explanations appear after […]
FDA Approves New First-Line Standard of Care in Bladder Cancer
Patients with locally advanced or metastatic bladder cancer have a permanent new first-line standard of care after the FDA granted full approval to the combination of enfortumab vedotin (Padcev) and pembrolizumab (Keytruda) regardless of cisplatin eligibility. The action finalized the approval process for the combination, which received accelerated approval earlier this year, at the time […]
Bilateral Mastectomy Not Tied to Better Survival in BRCA1-Positive Breast Cancer
SAN ANTONIO — Bilateral mastectomy as initial treatment for women with breast cancer and a pathogenic BRCA1 variant was not linked to better survival, according to an international analysis. Compared with breast-conserving treatment (BCT), bilateral mastectomy was not significantly associated with a reduction in mortality in this population of patients (HR 0.83, P=0.52), reported Kelly […]
Experts’ Hopes for the Future of dMMR Uterine Cancer Treatment
In this exclusive MedPage Today video, Susana Campos, MD, from the Dana-Farber Cancer Institute in Boston, and Richard Penson, MBBS, of Mass General Cancer Center at Massachusetts General Hospital in Boston, discuss how they see uterine cancer treatment evolving in 2024. Following is a transcript of their remarks: Campos: In terms of what’s maybe on […]