Metastasis-Directed Therapy May Delay ADT in Advanced Prostate Cancer
Metastasis-directed therapy (MDT) in selected patients with recurrent oligometastatic prostate cancer led to PSA responses in a majority of patients and delayed initiation of hormonal therapy by 18 months, a retrospective study showed. Overall, 77 of 124 patients had PSA declines of more than 50% with surgery or stereotactic body radiation therapy (SBRT). In particular, […]
One Dose of Acoziborole Led to Cure of ‘Sleeping Sickness’ Across Disease Stages
A single dose of oral acoziborole proved to be efficacious and safe for adults and adolescents with gambiense human African trypanosomiasis (HAT), also known as “sleeping sickness,” suggesting its promise in interrupting transmission, a single-arm phase II/III trial showed. Over 18 months of follow-up, the treatment success rate was 95.2% in those with late-stage disease […]
Shaking less salt on your food at the table could reduce heart disease risk: Researchers found a link between a lower frequency of dietary salt and a reduced CVD risk
Adding additional salt to foods at a lower frequency is associated with a reduced risk of heart disease, heart failure and ischemic heart disease, according to a new study published today in the Journal of the American College of Cardiology. Even among those following a DASH-style diet, behavioral interventions to lessen salt consumption could further […]
Lung Cancer Survival High for Patients With Early, Screen-Detected Tumors
CHICAGO — The diagnosis of early-stage lung cancer with low-dose CT (LDCT) screening led to high rates of lung cancer-specific survival two decades later, according to I-ELCAP data. The 20-year lung cancer-specific survival rate was 80% for the 1,285 I-ELCAP participants diagnosed with early-stage disease, reported Claudia Henschke, MD, PhD, of Mount Sinai Icahn School […]
HHS Proposes Rule to Ensure Better Care Coordination for Patients With SUD
In an effort to enhance care coordination for patients with substance use disorder (SUD), HHS, acting through its Office for Civil Rights and in collaboration with the Substance Abuse and Mental Health Services Administration, proposed changes to “Part 2” rules to better align privacy measures with those of HIPAA on Monday. If implemented, the proposed […]
Clinical Challenges: Thromboembolic Risk in Pediatric Cardiomyopathy
Children with cardiomyopathy are one of the highest-risk pediatric groups for developing thrombosis, along with kids with Fontan circulation, systemic-to-pulmonary artery shunt-dependent functionally univentricular circulation, central lines, and Kawasaki disease with coronary aneurysms. Prophylaxis to prevent thromboembolism and associated complications for children with cardiac disease is most commonly done with antiplatelets (such as aspirin and […]
Clinical Challenges: Therapeutic Options for AOSD
Rheumatologists primarily treat patients diagnosed with adult-onset Still’s disease (AOSD) empirically and based on sporadic cases, retrospective case studies, and small clinical trials. “You want to help these people,” said Nilanjana Bose, MD, MBA, a rheumatologist at Lonestar Rheumatology in Houston. “Oftentimes these patients go from doctor to doctor and no one knows what is […]
Robotic Surgery Proves Its Mettle for Liver Cancer
Fully robotic liver resection was safe and effective for patients with hepatocellular carcinoma (HCC) compared with open liver resection, a cohort study found. Propensity score-matched analysis showed “better perioperative tolerability … based on clinical, oncologic, and technical criteria” compared with open resection, reported Fabrizio Di Benedetto, MD, PhD, of the University of Modena and Reggio […]
Antioxidant flavonols linked to slower memory decline: Fruits, vegetables, tea may be helpful
People who eat or drink more foods with antioxidant flavonols, which are found in several fruits and vegetables as well as tea and wine, may have a slower rate of memory decline, according to a study published in the November 22, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. […]
More And More People Are ‘Kidulting.’ Maybe You Should, Too.
At the height of the pandemic, I kidulted plenty. To kidult ― I know it sounds obnoxious, but bear with me ― is to recreate childhood memories by partaking in activities generally considered for children. In my case, I clocked in more hours of “Animal Crossing” than I care to admit (mostly because my island […]