Monoclonal Antibodies Linked to Reduced RSV Burden in Young Kids
Prophylactic use of three monoclonal antibodies was associated with substantial reductions in respiratory syncytial virus (RSV)-related infections and hospitalizations in children under 5, a systematic review and meta-analysis showed. Across 14 randomized controlled trials involving over 18,000 high-risk children, moderate- to high-certainty evidence showed that nirsevimab, palivizumab, and motavizumab were associated with significant reductions in […]
Rucaparib Gets a Win in Metastatic Castration-Resistant Prostate Cancer
SAN FRANCISCO — Imaging-based progression-free survival (PFS) was significantly longer with the PARP inhibitor rucaparib (Rubraca) compared with physician’s choice of therapy in patients with BRCA or ATM-associated metastatic castration-resistant prostate cancer (CRPC), the phase III TRITON3 study showed. All patients in the study had already progressed after treatment with a second-generation androgen receptor-pathway inhibitor […]
Bruce Willis Diagnosed With Frontotemporal Dementia, Family Says
Actor Bruce Willis has been diagnosed with frontotemporal dementia, his family said in a statement Thursday. The 67-year-old “Die Hard” star was diagnosed with the disease, also known as FTD, after his prior diagnosis of aphasia progressed, his family said. Advertisement “Unfortunately, challenges with communication are just one symptom of the disease Bruce faces. While […]
Reassuring Findings on Bivalent COVID Booster in Hemodialysis Patients
Anti-spike IgG concentrations against BA.4/5 significantly increased in patients with end-stage renal disease (ESRD) following a bivalent booster, particularly in those without a prior Omicron infection, a case series from Germany found. The study looked at 55 ESRD patients on hemodialysis who had received four prior doses of a monovalent vaccine, including about a third […]
Comorbidity Burden in People With HIV Tied to Increased Mortality Risk
The prevalence of comorbidities in people with HIV on effective antiretroviral treatment was consistently higher compared with HIV-negative individuals, and was linked to an increased risk for death, according to a prospective longitudinal cohort study. In people age 45 and older followed for a median 5.9 years, 5.2% of the 596 HIV-positive participants died compared […]
Women With Hypertension During Pregnancy Face Higher CVD Risks
Women with hypertensive disorders of pregnancy (HDP) were at a significant risk for developing new cardiovascular disease (CVD) within a couple of years of giving birth, a researcher reported. Within 2 years postpartum, patients with HDP had almost two times the risk for cerebrovascular disease, nearly three times the risk for cardiomyopathy and heart failure […]
Oral Drug Shows Benefit for Notalgia Paresthetica in Mid-Stage Trial
A selective kappa opioid receptor agonist in patients with notalgia paresthetica led to “modestly” greater improvements in itchiness over placebo, but was associated with adverse events, a randomized phase II trial showed. At 8 weeks, improvements in average itchiness was significantly greater with oral difelikefalin (Korsuva) versus placebo on the Worst Itch Numeric Rating Scale […]
Phthalates Exposure Tied to Higher Incidence of Type 2 Diabetes in White Women
Exposure to phthalates — a type of endocrine-disrupting chemical — was linked with a higher incidence of type 2 diabetes among women, but only those who were white, researchers reported. In a study of over 1,300 women without diabetes, certain phthalate metabolites were associated with a higher incidence of diabetes during 6-year follow-up in a […]
Adding Docetaxel to RT Improves Survival in Cisplatin-Ineligible Head & Neck Cancer
Adding docetaxel to radiation therapy (RT) improved survival outcomes in cisplatin-ineligible patients with locally advanced head and neck squamous cell carcinoma, a phase III randomized trial showed. At a median follow-up of 32.4 months, the 2-year disease-free survival (DFS) rate was 42% with docetaxel plus RT and 30.3% with RT alone (HR 0.673, 95% CI […]
High-Impact Fitness Equipment That Even The Smallest Home Gyms Can Accommodate
Amazon The Perfect Pushup handles, a dumbbells set and a stair stepper with bands. Despite genuinely enjoying working out, I am still extremely gym-averse. I’ll hit a pilates class on the weekends, but now that we are in the midst of the bleak dead of winter and temperatures have plummeted, I’m all about a exercising […]