Combo Falters in Papillary Renal Cancer, but Some Promise in MET-Driven Subset
Treatment with an investigational MET inhibitor plus a PD-L1 inhibitor induced responses in fewer than a third of patients with metastatic papillary renal cancer, but the combination showed promise for one subgroup, findings from the phase II CALYPSO trial showed. In the single-arm study, 12 of 41 patients (29%, 95% CI 16-46) had a confirmed […]
Opinion | Ashish Jha on the End of the COVID-19 Public Health Emergency
This video is part of an ongoing series of interviews with government leaders in healthcare. In this video, Jeremy Faust, MD, editor-in-chief of MedPage Today, and Ashish Jha, MD, MPH, the White House COVID-19 Response Coordinator for the Biden administration, discuss the end of the COVID-19 public health emergency (PHE) in May and what that […]
Long-Acting Injectable HIV Regimen on Par With Daily Drugs
SEATTLE — People living with HIV who have maintained undetectable virus levels with daily oral treatment could safely ditch the pills and transition to a more convenient every 2-month injectable alternative — without sacrificing efficacy, researchers found. In the 12-month results of the SOLAR trial, switching to the injectable long-acting cabotegravir plus rilpivirine (Cabenuva) from […]
Severe Mpox in Advanced HIV Patients Tied to Complications, Death
SEATTLE — Among people living with HIV, a severe form of mpox in the context of immunosuppression appeared to lead to complications and even death, according to a global case series. In a cohort of 382 patients, severe complications most commonly occurred in those with a CD4 cell count <100 cells/mm3 compared with those with […]
Can Coke ‘Enhance’ Men? Why Nurses Quit; Fetus Illegally Detained, Lawyer Says
Note that some links may require subscriptions. Do things grow better with Coke? Chinese researchers found that male mice who drank either Coke or Pepsi ended up with larger testicles than a control group of mice who drank tap water. (Daily Mail) Infant formula maker Reckitt said it is recalling 145,000 cans of its Enfamil […]
The Most Unexpected Sign Someone Is Having Suicidal Thoughts
miniseries via Getty Images Experts share what to do if someone has been struggling with their mental health and suddenly has a drastic shift in their outlook. When you first picture someone experiencing suicidal thoughts, you might imagine them crying, lying in bed, alone or in pain. Suicidal ideation — and the depression that can […]
Better Cognition Even With Small Amounts of Physical Activity
Being and remaining physically active throughout adulthood was linked with higher cognition at age 69, a longitudinal cohort study showed. Effect sizes were similar across all adult ages, suggesting that being physically active at any time in adulthood — even as little as once a month — was tied to higher cognition, reported Sarah-Naomi James, […]
Opinion | Death Literacy Among Healthcare Professionals Is Dismal
During a recent meeting with our hospice team, several staff members raised concerns about the limited understanding of the signs of dying and appropriate interventions to care for patients at the end of life. This is a particular challenge in the facilities where our patients reside — nursing homes and assisted living facilities. In another […]
Pembrolizumab Active in BCG-Unresponsive Papillary High-Risk Bladder Cancer
SAN FRANCISCO — Pembrolizumab (Keytruda) monotherapy showed encouraging antitumor activity in patients with papillary high-risk non-muscle-invasive bladder cancer (HR NMIBC) that was unresponsive to Bacillus Calmette-Guerin (BCG) treatment. In a cohort of patients in the KEYNOTE-057 study who had 45 months of follow-up, those treated with pembrolizumab (n=32) had an estimated 12-month disease-free survival (DFS) […]
Adding Talazoparib to Enzalutamide Boosts PFS in Metastatic Prostate Cancer
SAN FRANCISCO — Treatment with the PARP inhibitor talazoparib (Talzenna) plus enzalutamide (Xtandi) significantly improved radiographic progression-free survival (rPFS) compared with enzalutamide plus placebo in patients with metastatic castration-resistant prostate cancer (mCRPC), the phase III TALAPRO-2 trial showed. Among 805 randomized patients, rPFS assessed by blinded independent central review was not reached in those who […]