Do Away With ‘Lockout’ Period in iPLEDGE, FDA Advisors Urge
An FDA advisory committee on Wednesday voted 17-4 (with one abstention) to recommend removing a “lockout period” from a risk evaluation and mitigation strategy (REMS) for isotretinoin prescribing that requires patients to wait an extra 19 days — and take an additional pregnancy test — if they miss a 7-day window for picking up their […]
Dieting: Brain amplifies signal of hunger synapses: Possible target for drugs to combat the yo-yo effect
Many people who have dieted are familiar with the yo-yo effect: after the diet, the kilos are quickly put back on. Researchers from the Max Planck Institute for Metabolism Research and Harvard Medical School have now shown in mice that communication in the brain changes during a diet: The nerve cells that mediate the feeling […]
Hayden Panettiere Says She Thought Alcohol Would Fix Postpartum Depression
Hayden Panettiere recently opened up about her struggles with alcohol and postpartum depression after giving birth to her daughter in 2014. “I wish I knew about postpartum depression. I wish I knew to look out for it,” Panettiere said in an interview with E! News published Friday. The actor added that she didn’t know of […]
CDK4/6 Inhibition Active in Recurrent Low-Grade Serous Ovarian Cancer
TAMPA, Fla. — About a fourth of patients with recurrent low-grade serous ovarian cancer (LGSOC) obtained durable responses to the combination of CDK4/6 inhibitor ribociclib (Kisqali) and letrozole, a small single-arm trial showed. Overall, 23% of 48 patients had partial responses, increasing to 26% in those who had baseline and confirmatory CT scans. Almost 80% […]
Doc Moms, Mind the Gap — $3M Earning Difference by Sex
During a 40-year career, the average female physician with children made $3 million less than the average male physician with children — nearly double the male-female earnings gap experienced by single physicians, according to a national study of 95,000 physicians. In a cross-sectional analysis of surveys conducted from 2005 to 2019, female physicians earned as […]
Paxlovid May Lower Long COVID Risk, VA Study Suggests
Use of nirmatrelvir-ritonavir (Paxlovid) in older adults with risk factors for severe disease was associated with a roughly 25% lower risk of a post-COVID condition (PCC), a retrospective study of Veterans Affairs data showed. In the cohort of over 280,000 patients with a confirmed COVID case, 13% of those prescribed nirmatrelvir-ritonavir went on to develop […]
Does Taking Magnesium Really Help With Sleep And Brain Fog?
Illustration:Jianan Liu Does magnesium really help with constipation, stress, sleep and migraines? Experts share their thoughts. If you’ve been on social media recently, you’ve likely seen people touting the benefits of magnesium (and the different types of magnesium). Influencers ― and even some doctors ― on social media platforms claim it can improve almost everything, […]
Pregnant, Black? Here’s Your Drug Test
Perinatal care differs by race and ethnicity, with greater disparities in care for more stigmatizing conditions such as depression and substance use, according to a retrospective study. For example, compared with white women, Black women were less likely to receive a prenatal depression screen (OR 0.8, 95% CI 0.7-0.9) and more likely to be given […]
Progestin-Only Birth Control Linked to Small Increase in Breast Cancer Risk
Current or recent use of progestin-only contraceptives was associated with a small increase in risk of breast cancer, similar to the risk associated with combined hormonal contraceptives, according to a nested case-control study and meta-analysis from the U.K. In the nested case-control study of data from the Clinical Practice Research Datalink, women had a comparable […]
Ed Sheeran Opens Up About Body Image, Eating Disorder: ‘I’m A Real Binge Eater’
With his return to the spotlight now imminent, Ed Sheeran is opening up about the private turmoil that’s reflected in his latest artistic output. Sheeran, a four-time Grammy winner, graces the April cover of Rolling Stone and, in the accompanying interview, speaks at length about his new album, “Subtract,” and Disney+ docuseries, “The Sum of […]