High-Sensitivity Troponin Test May Overestimate Risk in PE
For patients with hemodynamically stable pulmonary embolism (PE), there was no prognostic value found for the mild elevations in cardiac troponin captured only on high-sensitivity assays at the emergency room, based on an exploratory analysis of the PROTECT cohort study. Whereas a finding of conventional cardiac troponin I (cTnI) elevation was associated with a complicated […]
Mahvash Disease Case Resolved With Liver Transplantation
A woman with Mahvash disease presented with portal hypertension that necessitated liver transplantation; the liver complications observed in this case report distinguish it from what’s more typically seen in patients with this condition. The 27-year-old woman presented with mildly elevated aminotransferase levels and chronic pancreatitis after having experienced three episodes of hematemesis. Although her imaging […]
Longer Use of ADHD Meds May Boost Heart Risk
Longer use of attention deficit-hyperactivity disorder (ADHD) medication was associated with an increased risk of cardiovascular disease, particularly hypertension and arterial disease, a nested case-control study from Sweden showed. Risk of cardiovascular disease rose with longer cumulative exposure to the drugs, peaking at 3 to 5 years of use (adjusted odds ratio [AOR] 1.27, 95% […]
Longer Use of ADHD Meds May Boost Heart Risk
Longer use of attention deficit-hyperactivity disorder (ADHD) medication was associated with an increased risk of cardiovascular disease, particularly hypertension and arterial disease, a nested case-control study from Sweden showed. Risk of cardiovascular disease rose with longer cumulative exposure to the drugs, peaking at 3 to 5 years of use (adjusted odds ratio [AOR] 1.27, 95% […]
Apixaban Prophylaxis Fails to Reduce Clots in Pediatric ALL
Prophylaxis with apixaban (Eliquis) failed to reduce the rate of venous thromboembolism (VTE) in children with newly diagnosed acute lymphoblastic leukemia or lymphoma, according to results from the phase III randomized PREVAPIX-ALL study. During a median follow-up of 27 days, 12% of patients receiving the direct oral anticoagulant had a composite VTE compared with 18% […]
Proteins Predict Signs of Alzheimer’s Disease
Protein indicators of subclinical peripheral heath in plasma were linked with markers of Alzheimer’s disease and neurodegeneration, cross-sectional proteomic analyses showed. Greater protein-based risk for cardiovascular disease, heart failure mortality, and kidney disease was associated with plasma biomarkers of amyloid-beta, phosphorylated tau181 (p-tau181), neurofilament light (NfL, a measure of neuronal injury), and glial fibrillary acidic […]
Why do some people get headaches from drinking red wine?
A red wine may pair nicely with the upcoming Thanksgiving meal. But for some people, drinking red wine even in small amounts causes a headache. Typically, a “red wine headache” can occur within 30 minutes to three hours after drinking as little as a small glass of wine. What in wine causes headaches? In a […]
Impaired Neurodevelopment in Preemies Screened for Retinopathy: Nature or Nurture?
Having public health insurance was associated with an increased risk of neurodevelopmental impairment among infants screened for retinopathy of prematurity (ROP), a retrospective cohort study suggested. In a diverse cohort of 706 premature neonates, public heath insurance was associated with an increased risk of moderate to severe neurodevelopmental impairment in cognitive and language domains, and […]
DOAC Cuts Stroke Risk From Subclinical Afib
PHILADELPHIA — For patients with subclinical atrial fibrillation (Afib, AF) detected by their pacemaker or defibrillator, direct oral anticoagulation brought their already low stroke risk even lower — but at a cost in bleeding events, the ARTESiA trial showed. Apixaban (Eliquis) treatment cut risk of stroke or systemic embolism 37% compared with low-dose aspirin over […]
Consequences of Oral Anticoagulant Choice Magnified in the Frail
Older adults with atrial fibrillation (Afib, or AF), especially those with frailty, had better patient-centered outcomes taking apixaban (Eliquis) than other common oral anticoagulants (OACs), Medicare records showed. Compared with apixaban, rivaroxaban (Xarelto) was associated with significantly increased risk of spending more than 14 days in the hospital or a skilled nursing facility during follow-up […]