Novel Antibiotic Combo Bests Meropenem for Complicated UTIs
Cefepime-taniborbactam, an investigational beta-lactam and beta-lactamase inhibitor combination, was superior to meropenem for the treatment of hospitalized patients with complicated urinary tract infection (UTI), including acute pyelonephritis, a phase III randomized study showed. In the microbiologic intention-to-treat (ITT) population, the composite microbiologic and clinical success rate with the combination at test-of-cure (trial days 19 to […]
Novel Oral Antibiotic Effective Against Uncomplicated UTIs
Gepotidacin — a first-in-class oral antibiotic — appeared effective and safe for the treatment of uncomplicated urinary tract infections (UTIs) in a pair of large, phase III non-inferiority studies. In the two trials — EAGLE-2 and EAGLE-3 — the therapy was shown to be noninferior to nitrofurantoin, an antibiotic commonly used as a first-line therapy […]
King Charles III Has Cancer
Britain’s King Charles III has been diagnosed with cancer and has begun treatment, Buckingham Palace said Monday. Less than 18 months into his reign, the 75-year-old monarch will suspend public engagements but will continue with state business, and won’t be handing over his constitutional roles as head of state. The palace didn’t disclose what form […]
Effective Treatments Identified for Pediatric Complication of COVID
PHOENIX — First-line treatment with methylprednisolone and second-line treatment with tocilizumab (Actemra) shortened hospital stays for children with pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS; also referred to as multisystem inflammatory syndrome in children [MIS-C]), according to results of a two-stage clinical trial from the RECOVERY collaborative group. In 214 children randomly assigned […]
CAR-T Investigation: FDA Leaders Detail Decision on Cancer Risk Warning
The FDA has identified more cases of secondary T-cell malignancies following treatment with chimeric antigen receptor (CAR) T-cell therapies, cases that led the agency to demand new boxed warnings on approved agents in the class. With about 27,000 doses of the six B-cell maturation antigen (BCMA)- or CD19-directed CAR-T products having been administered in the […]
Role of ‘hunger hormone’ receptor in obesity-realted chronic inflammation
Texas A&M AgriLife Research study may lead to novel obesity treatment New study provides insights on role of ‘hunger hormone’ receptor in obesity-realted chronic inflammation A team comprised primarily of Texas A&M AgriLife Research scientists has made an important discovery that could lead to a novel treatment for obesity and obesity-associated diseases or conditions. Details […]
Fracture Risk Bumped With Testosterone Therapy in Hypogonadal Men
Testosterone treatment didn’t offer protection against fractures in men with hypogonadism, a TRAVERSE subtrial indicated. Compared with placebo, men who were on a testosterone gel actually had a significantly higher risk for fracture (HR 1.43, 95% CI 1.04-1.97), found Peter Snyder, MD, of the University of Pennsylvania in Philadelphia, and colleagues. During the median 3.19-year […]
Add-On Clarithromycin Pans Out in Community-Acquired Pneumonia Trial
In a phase III trial, the addition of oral clarithromycin to beta-lactam antibiotic treatment improved the clinical response of people with community-acquired pneumonia who had systemic inflammatory response syndrome, findings that support existing guidelines. In the study, the proportion of patients meeting the primary composite endpoint after 72 hours of treatment — fulfilling criteria for […]
Study Assuages Fears of Pancreatic Cancer Risk With GLP-1 Receptor Agonists
Several years after initiating treatment, GLP-1 receptor agonist users didn’t have a pancreatic cancer safety signal, a historical cohort study reported. Compared with basal insulin users, those on a GLP-1 receptor agonist didn’t have a significantly different risk for developing pancreatic cancer in the 5 to 7 years that followed (HR 0.50, 95% CI 0.15-1.71), […]
Shorter Antibiotic Course Noninferior for UTI Recurrence in Kids
Five days of oral antibiotic treatment for febrile urinary tract infections (UTIs) in kids was noninferior to the standard 10-day course, the randomized controlled STOP trial showed. The recurrence rate of all UTIs — febrile and non-febrile — within 30 days of treatment with oral amoxicillin-clavulanate acid was 2.8% in the short-term group compared with […]