Does ‘bridging’ therapy improve outcome for people with stroke? Meta-analysis finds clot-busting drug followed by clot removal works best
There has been debate over the best treatment for a certain type of stroke caused by a blockage of a large artery in the brain. A new meta-analysis finds that people who have this kind of stroke who can be treated within four-and-a-half hours after their symptoms start may do better after their stroke when […]
AI for Radiation Therapy Works, but Is it Fully Trusted?
The use of artificial intelligence in creating radiation treatment plans for prostate cancer appeared to be a success, according to a blinded, head-to-head study. Overall, radiation oncologists considered the vast majority — 89 of 100 — of machine learning (ML)-generated plans clinically acceptable for treatment, reported Thomas Purdie, PhD, and colleagues at Princess Margaret Cancer […]
Stem cell discoveries hold potential to improve cancer treatment: Findings could lead to new ways to fight disease and help patients recover faster
Two recent discoveries by stem cell scientists at Cedars-Sinai may help make cancer treatment more efficient and shorten the time it takes for people to recover from radiation and chemotherapy. In the first study, published in the journal Blood, investigators discovered a protein that is expressed by blood stem cells that could aid in identifying, […]
What Is the Best Treatment for Mental Illness? (8 Options)
8 treatment options for mental illnesses Taking care of your mental health means creating a balance between life activities and responsibilities, as well as the following 8 treatment options. Mental health and stress management are important aspects that can save your ability to appreciate life and affect your productivity. Taking care of your mental health […]
Tangled messages: Tracing neural circuits to chemotherapy’s ‘constellation of side effects’: Neural pathways behind complex sensory and motor side effects of chemotherapy
Severe and persistent disability often undermines the life-saving benefits of cancer treatment. Pain and fatigue — together with sensory, motor, and cognitive disorders — are chief among the constellation of side effects that occur with the platinum-based agents used widely in chemotherapy treatments worldwide. A new study by Georgia Tech researchers in the lab of […]
How CAR T-Cell Therapy Measures Up in Follicular Lymphoma
In relapsed or refractory follicular lymphoma, treatment with the chimeric antigen receptor (CAR) T-cell therapy axicabtagene ciloleucel (axi-cel, Yescarta) was associated with better outcomes compared with currently available therapies, a comparative analysis of the ZUMA-5 and SCHOLAR-5 trials suggested. Overall response rate (ORR) was higher, and both progression-free survival (PFS) and overall survival (OS) were […]
In Early Prostate Cancer, Black Men Do Better With Radiotherapy Than White Men
Black men with localized prostate cancer had better treatment- and disease-specific outcomes than white men when treated with definitive radiotherapy, according to the results of a meta-analysis. Even though Black men were more likely to present with high-risk features, they were less likely to experience biochemical recurrence (subdistribution hazard ratio [sHR] 0.88, 95% CI 0.80-0.96, […]
International study supports dupilumab for treatment of moderate-to-severe asthma in children
A new medication has been added to the treatment options for children with moderate-to-severe asthma. In a late-stage clinical trial, the biologic agent dupilumab reduced the rate of severe asthma attacks and improved lung function and asthma control for children ages 6 to 11. The findings of the international multicenter Liberty Asthma VOYAGE trial, reported […]
Zanubrutinib Tops Ibrutinib in Relapsed or Refractory CLL
Treatment with the second-generation Bruton tyrosine kinase (BTK) inhibitor led to better oncologic outcomes compared with ibrutinib (Imbruvica) for patients with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL), according to an interim analysis of the phase III ALPINE study. Over a median follow-up of 15 months, the overall response rate — the primary […]
FDA OKs PD-1 Inhibitor for Adjuvant Treatment of Kidney Cancer
The FDA approved pembrolizumab (Keytruda) for the adjuvant treatment of renal cell carcinoma (RCC) for patients who have an intermediate-high or high risk of recurrence following nephrectomy, or following nephrectomy and resection of metastatic lesions, the agency announced. Approval was based on results from the KEYNOTE-564 trial, which demonstrated that adjuvant pembrolizumab following nephrectomy significantly […]