Novel Drug Cuts Proteinuria in APOL1-Mediated Kidney Disease
An investigative treatment targeting APOL1 activity significantly improved proteinuria APOL1-mediated kidney disease (AMKD), a proof-of-concept phase IIa study found. In a single-arm, open-label study, treatment with oral VX-147 — a small molecule acting as an APOL1 function inhibitor — significantly reduced urine protein to creatinine ratio (UPCR) by 47.6% (95% CI -60 to -31.3%) by […]
Kisspeptin: A new drug to treat liver disease? Rutgers researchers discover hormone has therapeutic effects on non-alcoholic fatty liver disease in mouse study
A hormone that triggers puberty and controls fertility in humans might be developed as a treatment for non-alcoholic fatty liver disease, according to new Rutgers research. The study, appearing in the Journal of Clinical Investigation, provides powerful evidence that a modified version of the naturally occurring hormone kisspeptin can be used to treat non-alcoholic fatty […]
Kisspeptin: A new drug to treat liver disease? Rutgers researchers discover hormone has therapeutic effects on non-alcoholic fatty liver disease in mouse study
A hormone that triggers puberty and controls fertility in humans might be developed as a treatment for non-alcoholic fatty liver disease, according to new Rutgers research. The study, appearing in the Journal of Clinical Investigation, provides powerful evidence that a modified version of the naturally occurring hormone kisspeptin can be used to treat non-alcoholic fatty […]
Add-On Mavacamten Cuts Need for Septal Reduction in Obstructive HCM
WASHINGTON – Treatment with investigational mavacamten allowed patients with advanced obstructive hypertrophic cardiomyopathy (oHCM) to avoid septal reduction therapies (SRT), a researcher reported. In the VALOR-HCM study among 56 patients with documented oHCM who received add-on mavacamten to maximally-tolerated medical therapy, 17.9% met the composite endpoint (decision to move to SRT by week 16 or […]
How Is Substance-Induced Psychosis Treated? Drug Abuse Symptoms
Substance-induced psychosis is initially treated by cessation of the substance causing psychosis and the following treatment plans. The initial treatment for substance-induced psychosis is the cessation of the substance that causes psychosis and monitoring the person in a safe and calm environment. Some of the drugs commonly prescribed for the treatment of substance-induced psychosis include: […]
Simpler Antifungal Course Works for Cryptococcal Meningitis in Africa
A single high-dose course of liposomal amphotericin B as part of a three-drug antifungal treatment regimen was non-inferior to the current WHO-backed antifungal drug regimen for cryptococcal meningitis in people living with HIV, according to a phase III trial. In an intention-to-treat (ITT) analysis of 814 patients, 101 deaths were reported in the intervention group […]
Do ‘behavioral psychedelics’ help patients make lasting, positive change?
Despite their reputation as illicit drugs, psychedelics may find new, legitimate roles in treatment for anxiety, depression, stress disorders, addiction, and other mental and behavioral health problems. But ensuring they do requires developing rigorous, standardized methods to study and apply the results, according to a new report. In a perspective published in Frontiers in Psychiatry, […]
Dupilumab May Help in Tough-to-Treat Chronic Spontaneous Urticaria
PHOENIX — Patients who received add-on dupilumab (Dupixent) treatment for chronic spontaneous urticaria (CSU) had reduced symptoms and experienced less itchiness, a phase III trial found. In the 6-month study, participants (adults, adolescents, and children) treated with dupilumab on top of their usual H1-antihistamine (H1-AH) experienced a 4.2-point greater mean reduction in their Itch Severity […]
Does Grandma Need Surgery for That Broken Wrist?
Patient-reported outcomes 2 years after treatment for distal wrist fractures didn’t differ significantly in older patients irrespective of the therapy chosen, including simple casting, a randomized trial showed. That was true even for participants who chose casting and experienced malunion during recovery with visible, permanent deformity, according to Kevin C. Chung, MD, MS, of the […]
Darolutamide Improves OS in Metastatic Prostate Cancer
Darolutamide (Nubeqa) combined with standard treatment significantly improved survival in patients with metastatic hormone-sensitive prostate cancer (mHSPC), the phase III ARASENS trial found. At data cutoff, patients who received darolutamide plus androgen deprivation therapy (ADT) and docetaxel had a 32.5% lower risk of death compared with the group who received placebo plus the standard (HR […]