Psych Nurses Sound the Alarm on Patient Violence at Pediatric Hospital
Nurses at Seattle Children’s Hospital demanded the hospital intervene after police were twice called to the Psychiatry and Behavioral Medicine Unit (PBMU) over violent incidents during a 2-week period in November, according to the Washington State Nurses Association (WSNA). On November 7, police were called to intervene after patients began overturning carts, wielding metal poles […]
Pegcetacoplan-Related Eye Inflammation: The Search Is on for Answers
SEATTLE — Reports of unexpected panuveitis and retinal occlusive vascular disease associated with pegcetacoplan (Syfovre) treatment has triggered a search for answers by ophthalmologists and the drug’s manufacturer. Since July 3, the American Society of Retina Specialists (ASRS) Research and Safety in Therapeutics (ReST) Committee has learned of seven cases of retinal inflammation and vascular […]
Adding This New Criteria Drastically Cut 72-Hour Insulinoma Fast Time
SEATTLE — Adding beta-hydroxybutyrate (BHB) stopping criteria cut down fasting time when detecting insulinomas in patients with hypoglycemia, according to late-breaking findings presented here. By adding in a stopping point if BHB reached a level of 2.7 mmol/L or higher to the fasting protocol, fasting time was nearly 8 hours shorter on average across the […]
Benefits of Parathyroidectomy Run Far Deeper Than PTH Normalization
SEATTLE — Parathyroidectomy helped reverse disrupted levels of inflammatory cytokines and vitamin D metabolites in patients with primary hyperparathyroidism (PHPT), a researcher suggested here. After 50 patients, newly diagnosed with PHPT, underwent parathyroidectomy, serum intact parathyroid hormone (PTH) levels returned to the normal range within 3 months (115.6±38.9 to 42.6±24.5 pg/mL, P<0.001), said Xiangbing Wang […]
What Next After Early End of MOSAICO HIV Vaccine Trial?
SEATTLE — The abrupt and early end of the MOSAICO HIV vaccine trial, announced last month, was the topic of a special session at the Conference on Retroviruses and Opportunistic Infections here. Results of the 3,800-participant trial were negative, with an identical 113 individuals in the vaccine regimen and placebo groups becoming infected with HIV […]
Long-Acting Injectable HIV Regimen on Par With Daily Drugs
SEATTLE — People living with HIV who have maintained undetectable virus levels with daily oral treatment could safely ditch the pills and transition to a more convenient every 2-month injectable alternative — without sacrificing efficacy, researchers found. In the 12-month results of the SOLAR trial, switching to the injectable long-acting cabotegravir plus rilpivirine (Cabenuva) from […]
Severe Mpox in Advanced HIV Patients Tied to Complications, Death
SEATTLE — Among people living with HIV, a severe form of mpox in the context of immunosuppression appeared to lead to complications and even death, according to a global case series. In a cohort of 382 patients, severe complications most commonly occurred in those with a CD4 cell count <100 cells/mm3 compared with those with […]
Children’s HIV Deaths in Africa Largely Preventable
SEATTLE — More than half of the children who died from HIV-related illnesses in Africa were not diagnosed with HIV prior to their death, and nearly all of these deaths were preventable, data from the Child Health and Mortality Prevention Surveillance (CHAMPS) study indicated. Of more than 2,100 pediatric deaths captured in recent years across […]
Doxycycline Fails to Protect Women Against STIs
SEATTLE — Researchers were scratching their heads over findings that doxycycline prophylaxis failed to prevent sexually transmitted infections (STIs) among African cisgender women, unlike its success among men who have sex with men. In a trial conducted among 449 women in Kenya who were taking daily pre-exposure prophylaxis (PrEP) to prevent HIV infection, 50 of […]
Sutezolid With 3-Drug Combo Appears Safe and Effective in Multidrug-Resistant TB
SEATTLE — Adding the oxazolidinone antibiotic sutezolid to a three-drug combination appeared to be safe and effective for people with multidrug-resistant tuberculosis (TB), according to a dose-finding phase II study. Across five treatment arms that included four different doses of sutezolid with bedaquiline, delamanid, and moxifloxacin at standard doses, there was a similar increase in […]