Study Examines Off-Target Mortality in Cancer Screening
Cancer screening reduced targeted cancer mortality without significantly increasing deaths from other causes. Meta-analysis of 17 studies found a 0.2% increase in off-target mortality rates in screened patients. Results suggest a need to analyze on-target cancer mortality and off-target mortality separately in trials of cancer screening. Screening for cancer reduced targeted cancer mortality without a […]
PSA and Biomarker Testing Plus MRI Appears to Improve Prostate Cancer Screening
A single round of prostate cancer screening that included a prostate-specific antigen (PSA) test, a kallikrein panel, and an MRI detected one additional high-grade cancer per 196 men and one low-grade cancer per 909 men, according to preliminary results from the Finnish ProScreen randomized trial. The risk difference for the group randomized to the screening […]
Liquid Biopsy for CRC Screening May Not Be Ready for Prime Time
While screening for colorectal cancer (CRC) with a blood-based test would result in better outcomes than no screening at all, it would likely result in worse outcomes than currently available tests — while increasing costs — according to two modeling studies published in Gastroenterology. In the first, models suggested that compared with no screening at […]
5 Signs You Should Get A Colonoscopy Before You Turn 45
SDI Productions via Getty Images The recommended age to begin colonoscopy screening is 45, but some people should start sooner. It’s been frequently reported that colorectal cancer rates are increasing in young people in the United States. In fact, according to the American Cancer Society, cases of colorectal cancer in people 55 and under have […]
Two-Stage Screening Strategy for Ovarian Cancer Continues to Show Progress
A two-stage ovarian cancer screening strategy substantially improved early-stage detection among average-risk postmenopausal women, according to long-term follow-up from a large prospective study. Combining serial CA125 values and conditional referral for transvaginal sonography (TVS) led to a sensitivity of 74% for detection of ovarian and borderline cancers. Cancers detected by the Risk of Ovarian Cancer […]
CDC Backs Hepatitis C Screening for Kids Exposed in the Womb
The CDC released new recommendations for hepatitis C virus (HCV) screening among perinatally exposed infants and children. The four new recommendations detailed in the MMWR Recommendations and Reports are as follows: All perinatally exposed infants should be screened for HCV with a nucleic acid test (NAT) for detection of HCV RNA at ages 2 to […]
Medicaid Expansion Seen Lifting Colon Cancer Screening for Low-Income People
CHICAGO — Colorectal cancer screening rates at so-called Federally Qualified Health Centers (FQHCs) in 2021 were higher in states that had accepted funding from the federal government to expand access to Medicaid compared with those that had not, a researcher said here. But the data also suggested that Medicaid expansion didn’t eliminate all financial barriers […]
Deaths From PSA-Detected Prostate Cancer Low at 15 Years, No Matter the Treatment
For prostate cancers detected by screening, cancer-specific mortality was low at 15-year follow-up regardless of whether patients underwent active monitoring, prostatectomy, or radiotherapy, results from the phase III randomized ProtecT study showed. Among over 1,600 men from the U.K. with prostate cancers detected by a prostate-specific antigen (PSA) test, death from their malignancy occurred in […]
For People With HIV, Early Anal Cancer Screening Tied to Better Outcomes
Screening HIV-positive individuals for early signs of anal cancer may lead to an earlier diagnosis and better survival, according to an observational Dutch cohort study. Among men who have sex with men (MSM) living with HIV, anal cancer-related mortality was 3.7% in those who had been screened in the Netherlands compared with 24.0% in those […]
Lung Cancer Survival High for Patients With Early, Screen-Detected Tumors
CHICAGO — The diagnosis of early-stage lung cancer with low-dose CT (LDCT) screening led to high rates of lung cancer-specific survival two decades later, according to I-ELCAP data. The 20-year lung cancer-specific survival rate was 80% for the 1,285 I-ELCAP participants diagnosed with early-stage disease, reported Claudia Henschke, MD, PhD, of Mount Sinai Icahn School […]