Whopping Mortality Benefit in Severe COVID Trial
Treatment with a novel, oral microtubule disruptor significantly reduced the risk of death in hospitalized COVID-19 patients with severe disease, an interim analysis of a phase III study indicated. Mortality at 60 days, the international trial’s primary endpoint, was more than halved in the group assigned to investigational sabizabulin versus those randomized to placebo (20.2% […]
Drug Eases Migraine Days for Patients Who Failed Prior Treatments
Eptinezumab (Vyepti) reduced the number of monthly migraine days for people who had two to four previous migraine prevention treatment failures, the phase IIIb DELIVER trial showed. Changes in mean monthly migraine days were -4.8 for eptinezumab 100 mg, -5.3 eptinezumab for 300 mg, and -2.1 for placebo from baseline to weeks 1 to 12, […]
Early Anal Lesion Treatment Cuts Cancer Risk in People With HIV
Treating precancerous anal lesions in people with HIV reduced their risk of developing anal cancer by more than half compared with active monitoring, according to results from the ANCHOR study. In the randomized phase III trial of more than 4,500 individuals with anal high-grade squamous intraepithelial lesions (HSIL), nine of those assigned to treatment with […]
‘Traffic calming’ boosts breeding on coral reefs
Coral reef fish breed more successfully if motorboat noise is reduced, new research shows. Scientists introduced “traffic calming” on three reefs for an entire breeding season — cutting the number of boats within 100m, and reducing the speed of those within that distance. They then tracked the breeding of fish called spiny chromis — and […]
Low-Salt Diet Helpful for HF Symptoms, But Not Necessarily for Clinical Events
WASHINGTON — A dietary intervention reduced sodium intake, but did not reduce clinical events, for people with heart failure (HF), according to the SODIUM-HF trial. Between patients randomized to a low-sodium diet or usual care for 12 months, there was no statistically significant difference in the combined outcome of cardiovascular-related admissions to hospital, cardiovascular-related emergency […]
Video game-based therapy helps stroke patients
After a stroke, patients may lose feeling in an arm or experience weakness and reduced movement that limits their ability to complete basic daily activities. Traditional rehabilitation therapy is very intensive, time-consuming and can be both expensive and inconvenient, especially for rural patients travelling long distances to in-person therapy appointments. That’s why a team of […]
Two PARP Inhibitors Impress as First-Line Add-Ons in mCRPC
Adding PARP inhibition to first-line abiraterone (Zytiga) reduced the risk of radiographic progression or death in metastatic castration-resistant prostate cancer (mCRPC), a pair of phase III studies showed. In PROpel, patients who received olaparib (Lynparza) along with abiraterone plus prednisone had a roughly 8-month improvement in median radiographic progression-free survival (rPFS) versus those assigned placebo […]
Overweight dogs respond well to high-protein, high-fiber diet
A study of overweight dogs fed a reduced calorie, high-protein, high-fiber diet for 24 weeks found that the dogs’ body composition and inflammatory markers changed over time in ways that parallel the positive changes seen in humans on similar diets. The dogs achieved a healthier weight without losing too much muscle mass, and their serum […]
Tranexamic Acid Eased Blood Loss During Myomectomy
Among women with large uterine fibroids, the use of tranexamic acid (TXA) reduced blood loss during myomectomies, according to a retrospective cohort study. Patients who underwent a myomectomy to remove uterine fibroids with a total weight greater than 173 g had lower estimated blood loss after receiving TXA compared with those who did not (205.6 […]
Antibiotics Slow Down Latent Rheumatic Heart Disease in Kids
Antibiotic prophylaxis for screen-detected latent rheumatic heart disease reduced progression of disease in children, the GOAL trial showed. Echocardiographic progression was reduced to 0.8% at 2 years compared with 8.2% with no prophylaxis (P<0.001), reported Andrea Beaton, MD, of Cincinnati Children’s Hospital Medical Center, at the American Heart Association virtual meeting. The findings were simultaneously […]