‘Fantastic,’ ‘Terrific’ Results With Oncolytic Virus Combo for Bladder Cancer
CHICAGO — An oncolytic virus therapy combined with pembrolizumab (Keytruda) produced complete responses (CRs) in 85% of patients with bacillus Calmette-Guérin (BCG)-unresponsive non-muscle-invasive bladder cancer (NMIBC), a small phase II trial showed. The results showed CRs in 29 of 34 patients with detectable carcinoma in situ (CIS) treated with cretostimogene grenadenorepvec (CG0070) and the PD-1 […]
Study explores effects of dietary choline deficiency on neurologic and system-wide health: Reaching adequate dietary choline intake is critical to offset organ pathologies and may help protect the brain against Alzheimer’s disease
Choline, an essential nutrient produced in small amounts in the liver and found in foods including eggs, broccoli, beans, meat and poultry, is a vital ingredient for human health. A new study explores deficiency in dietary choline adversely affects the body and may be a missing piece in the puzzle of Alzheimer’s disease. It’s estimated […]
Zaire Ebola Vaccines Produce Antibody Responses as Early as 14 Days
Three vaccine regimens for Zaire Ebola virus disease (EVD) produced antibody responses in adults and children, according to the results of two randomized trials conducted in West Africa. At 12 months, 41% of adults and 78% of children had a response to the Ad26-MVA regimen (Ad26.ZEBOV followed by MVA-BN-Filo 56 days later), 76% and 87% […]
Increased heart disease risk from red meat may stem from gut microbe response to digestion
Chemicals produced in the digestive tract by gut microbes after eating red meat may help explain part of the higher risk of cardiovascular disease associated with red meat consumption, according to new research published today in the American Heart Association’s peer-reviewed journal Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB). In the United States and around the […]
Gaia space telescope rocks the science of asteroids
The European Gaia space mission has produced an unprecedented amount of new, improved, and detailed data for almost two billion objects in the Milky Way galaxy and the surrounding cosmos. The Gaia Data Release 3 on Monday revolutionizes our knowledge of the Solar System and the Milky Way and its satellite galaxies. The Gaia space […]
A single hormone directs body’s responses to low-protein diet: Mice live longer and lose weight while eating more when FGF21 is present
A single hormone appears to coordinate the lifespan extension produced by a low-protein diet. A new study from Pennington Biomedical Research Center, published in the journal Nature Communications, found that reducing the amount of protein in the diet produced an array of favorable health outcomes, including an extension of lifespan, and that these effects depend […]
‘Keto’ molecule may be useful in preventing and treating colorectal cancer, study suggests
A molecule produced in the liver in response to low-carb “ketogenic” diets has a powerful effect in suppressing colorectal tumor growth and may be useful as a preventive and treatment of such cancers, according to a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania. In the study, published […]
Immune cells produce chemical messenger that prevents heart disease–related inflammation
The immune system’s white blood cells, which are produced in the bone marrow, mostly help to defend against bacteria and injury, but sometimes they can turn against the body — for example, in cardiovascular disease, their inflammatory aggression can harm arteries and the heart. New research in Nature Immunology that was led by investigators at […]
Dramatic, Durable Hair Growth With Oral JAK Inhibitor
BOSTON — An oral Janus kinase (JAK) inhibitor produced significant, durable hair growth, including scalp, eyebrows, and eyelashes in patients with severe alopecia areata, according to long-term data from two randomized trials. Almost 40% of patients achieved a Severity of Alopecia Tool (SALT) score ≤20 (total percentage of hair loss) at 52 weeks with a […]
Visible ocean plastics just the tip of the iceberg: Simulations find the majority of ocean plastics may be on the seafloor or otherwise difficult to monitor, with vastly more plastic waste likely trapped on land
While the billions of tons of plastic products produced in the “Plastic Age” of the last half-century have drastically changed the way we live for the better, the plastic waste that has made it into the environment is posing new challenges for nature. Seeking to simulate the fate of plastics that have made it into […]