Non-Ablative Intervention for BPH/LUTS Reduces Symptoms With Low Retreatment Rate
LAS VEGAS — A novel, non-ablative intervention for lower urinary tract symptoms (LUTS) produced rapid, durable symptom relief with no adverse effect on sexual function, long-term results from prospective study showed. Five years after treatment with the Optilume BPH catheter system, urinary flow rate (Qmax) improved by 63% and post-void residual volume (PVR) remained substantially […]
High Response Rates in Psoriasis With Oral IL-23 Inhibitor
An oral interleukin (IL)-23 inhibitor for psoriasis produced 16-week response rates as high as 79% in moderate-to-severe plaque psoriasis, a prospective phase II trial showed. The drug (JNJ-77242113) achieved response rates of 37% to 79% across five dose levels. In contrast, patients treated with placebo had a 9% response rate at 16 weeks. The most […]
Liquid Biopsy Has Mixed Performance for Predicting Colon Cancer Outcomes
SAN FRANCISCO — In separate studies, liquid biopsy produced mixed results for guiding colon cancer treatment. Adjuvant chemotherapy guided by postoperative circulating tumor (ct) DNA did not lead to higher rates of DNA clearance as compared with patients who did not get chemotherapy. However, ctDNA did show promise for identifying patients with molecular residual disease […]
Low-Dose Intradermal Mpox Vaccine on Par With Subcutaneous Dosing
Mpox vaccination with a two-shot, low-dose intradermal approach produced similar antibody titers levels compared with the standard subcutaneous dosing regimen, an observational study showed. Two 0.1-mL intradermal doses of the modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine yielded geometric mean titers of immunoglobulin G (IgG) antibodies that neutralize mpox of 88.65 (95% CI 48.09-163.42), compared with […]
Hunger hormones impact decision-making brain area to drive behavior
A hunger hormone produced in the gut can directly impact a decision-making part of the brain in order to drive an animal’s behaviour, finds a new study by UCL (University College London) researchers. The study in mice, published in Neuron, is the first to show how hunger hormones can directly impact activity of the brain’s […]
Tyrosine Kinase Inhibitor Active in Heavily Treated Renal Cell Carcinoma
NASHVILLE, Tenn. — An investigational multitargeted drug produced objective responses in clear-cell renal cell carcinoma (ccRCC), irrespective of prior exposure to cabozantinib (Cabometyx), a small clinical trial showed. Overall, 12 of 32 patients responded to zanzalintinib, including four of 17 evaluable patients with prior exposure to cabozantinib and eight of 14 without. All but one […]
HER3-Targeted Drug Active in Advanced/Metastatic Breast Cancer
An antibody-drug conjugate (ADC) targeting HER3 produced objective responses in as many as 43% of patients with advanced breast cancer, a prospective clinical trial showed. Responses to patritumab deruxtecan (HER3-DXd) occurred in the three major types of breast cancer, ranging from 22.6% in triple-negative breast cancer (TNBC) to 30.1% in hormone receptor (HR)-positive/HER2-negative breast cancer […]
Comprehensive insulin signalling map shows interplay between genes and diet
Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a fundamental study of substantial importance. They say the authors share compelling evidence that sheds […]
Ultra-processed foods largely missing from US food policy: Few federal and state policies consider ultra-processed foods, but policy activity is growing
Ultra-processed foods — including industrially produced packaged snacks, fruit-flavored drinks, and hot dogs — have been linked to health issues ranging from weight gain to certain cancers. So where are the food policies helping Americans to steer clear of these foods? A new study published in the American Journal of Preventive Medicine finds that only […]
Taurine may be a key to longer and healthier life
A deficiency of taurine — a nutrient produced in the body and found in many foods — is a driver of aging in animals, according to a new study led by Columbia researchers and involving dozens of aging researchers around the world. The same study also found that taurine supplements can slow down the aging […]