An avocado a day may improve overall diet quality, researchers report
Eating one avocado per day may improve overall diet quality, according to a team led by researchers in Penn State’s Department of Nutritional Sciences. Poor diet quality is a risk factor for many diseases, including heart disease, and many American adults have poor diet quality and do not meet key dietary recommendations provided by the […]
Immune Checkpoint Inhibitor-Chemo Combo Boosts OS in Advanced Endometrial Cancer
SAN DIEGO — The addition of an immune checkpoint inhibitor (ICI) to chemotherapy up front improved overall survival (OS) in patients with advanced or recurrent endometrial cancer, regardless of mismatch repair (MMR) status, according to two trials. In the phase III RUBY Part 1, patients treated with dostarlimab (Jemperli) and chemotherapy had a median OS […]
Peripheral IV Access for Chemo Better Than Central Lines in Testicular Cancer?
Patients with testicular cancer had fewer venous access-related complications and overall thrombotic events when first-line chemotherapy was delivered via peripheral intravenous access compared with central venous access devices (CVADs), a retrospective study suggested. Among 154 patients, those in the CVAD group compared with the peripheral IV group experienced more venous access-related complications (52.2% vs 24.2%) […]
A Win and A Loss for Adjuvant ICIs in Clear Cell Renal Cell Carcinoma
SAN FRANCISCO — The use of adjuvant pembrolizumab (Keytruda) boosted overall survival (OS) in post-surgical patients with clear cell renal cell carcinoma (RCC) at risk for recurrence, according to KEYNOTE-564 findings. Patients treated with the immune checkpoint inhibitor (ICI) had a 38% reduced risk of death compared to patients on placebo, reported Tony Choueiri, MD, […]
Calorie restriction in humans builds strong muscle and stimulates healthy aging genes
Reducing overall calorie intake may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calories without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in […]
Disparities in Vision Testing for Adolescents
Decreased vision testing in primary care and in school settings drove an age-related overall decline in vision testing among adolescents, a review of national data showed. Data from 2018-2019 showed that three-fourths of adolescents had a vision test in some setting within the previous 12 months, though testing decreased with age (1.3% per year of […]
Study Validates Accuracy of PREDICT Prognostication Tool in Breast Cancer
The PREDICT prognostication tool was able to estimate overall survival (OS) with decent accuracy in a large independent U.S. dataset of breast cancer patients, researchers reported. From more than 700,000 patients in the National Cancer Database (NCDB), the free online tool estimated median and mean 5-year OS rates ranging from 83.3% to 84.4%, as compared […]
KRAS Mutations in Metastatic CRC Predict Survival Benefit of Chemo Combo
Codon-specific KRAS mutations are predictive of an overall survival (OS) benefit for metastatic colorectal cancer (mCRC) patients treated with trifluridine-tipiracil (FTD/TPI; Lonsurf), according to a genomics-based analysis. After identifying biomarkers of resistance and validating the findings in a real-world dataset, researchers showed that patients with KRAS G12-mutant tumors in the phase III RECOURSE trial achieved […]
Adding Targeted Drug to Chemo Boosts Survival in Esophageal/GEJ Cancer
SAN FRANCISCO — Adding a Claudin (CLDN) inhibitor to chemotherapy significantly increased progression-free (PFS) and overall survival (OS) in locally advanced gastric/gastroesophageal junction (GEJ) cancer and CLDN 18.2 expression, a randomized trial showed. Median PFS increased from 8.67 months with modified FOLFOX chemotherapy to 10.61 months with the addition of investigational zolbetuximab. Median OS improved […]
Role of Cytoreductive Nephrectomy Unclear for Dedifferentiated Kidney Cancer
AUSTIN, Texas — Cytoreductive nephrectomy improved overall survival (OS) by more than a year for patients with metastatic renal cell carcinoma (mRCC) with sarcomatoid or rhabdoid (S/R) dedifferentiation treated with immunotherapy in an observational study, but the difference did not achieve statistical significance. Median OS was 30 months with surgery versus 17 months without, representing […]