Do certain amino acids modify the risk of dementia linked to air pollution?
Higher levels of vitamin B-related amino acids may be linked to the risk of dementia associated with a certain type of air pollutants called particulate matter, according to a study published in the July 19, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study does not prove that […]
‘Exciting’ siRNA Therapy for Hypertension Passes First Hurdle
Patients with hypertension successfully dialed down their angiotensinogen levels and had lasting reductions in blood pressure (BP) following one injection of an investigational small interfering RNA (siRNA) therapy, according to a phase I study. In this first-in-human, placebo-controlled study, patients who received zilebesiran showed dose-dependent decreases in serum angiotensinogen levels and 24-hour ambulatory BP after […]
Dementia Tied to Fluctuations in Blood Lipids Over Time
Fluctuations in total cholesterol and triglyceride levels in people 60 and older were tied to a higher risk of incident dementia, including Alzheimer’s disease, a longitudinal study showed. Over a median follow-up of 12.9 years, participants in the highest quintile of total cholesterol variability versus the lowest quintile had a 19% increased risk of incident […]
Cardiorespiratory Fitness Levels May Influence Cancer Risk in Men
Cardiorespiratory fitness (CRF) levels may play a role in reducing the risk of developing and dying from certain common cancers in men, a prospective cohort study from Sweden suggested. Over a mean follow-up of 9.6 years among over 170,000 men, higher levels of CRF were associated with a significantly lower risk of incidence of colon […]
Higher Fetal Cortisol Levels Linked to Sleep Onset Delays
INDIANAPOLIS — Higher levels of neonatal hair cortisol, a measure of fetal cortisol production in the third trimester, may have a negative effect on sleep health among infants, according to a longitudinal study. Among 70 infants in the Care Project study, greater neonatal hair cortisol levels at birth predicted longer sleep onset latency at 7 […]
Novel Anti-HER2 Drugs ‘Impressive’ in Advanced Biliary Cancer
CHICAGO — In a pair of mid-stage trials, newer targeted therapies demonstrated meaningful levels of activity against HER2-positive biliary tract cancers in pretreated patients with advanced disease. Cohort 1 of the global HERIZON-BTC-01 study, which included 80 treatment-refractory patients, showed that 41.3% (95% CI 30.4-52.8) responded to zanidatamab, an investigational bispecific monoclonal antibody that targets […]
Benefits of Parathyroidectomy Run Far Deeper Than PTH Normalization
SEATTLE — Parathyroidectomy helped reverse disrupted levels of inflammatory cytokines and vitamin D metabolites in patients with primary hyperparathyroidism (PHPT), a researcher suggested here. After 50 patients, newly diagnosed with PHPT, underwent parathyroidectomy, serum intact parathyroid hormone (PTH) levels returned to the normal range within 3 months (115.6±38.9 to 42.6±24.5 pg/mL, P<0.001), said Xiangbing Wang […]
Elevated levels of toxic metals in some mixed-fruit juices and soft drinks
A new study has found that some commonly consumed beverages contained levels of toxic metals that exceed federal drinking water standards. Five of the 60 beverages tested contained levels of a toxic metal above federal drinking water standards, according to the study from Tulane University. Two mixed juices had levels of arsenic above the 10 […]
Long-Acting Injectable HIV Regimen on Par With Daily Drugs
SEATTLE — People living with HIV who have maintained undetectable virus levels with daily oral treatment could safely ditch the pills and transition to a more convenient every 2-month injectable alternative — without sacrificing efficacy, researchers found. In the 12-month results of the SOLAR trial, switching to the injectable long-acting cabotegravir plus rilpivirine (Cabenuva) from […]
The link between mental health and ADHD is strong — so why aren’t we paying attention?
Adults with high levels of attention-deficit hyperactivity disorder (ADHD) symptoms are more likely to experience anxiety and depression than adults with high levels of autistic traits, according to new research led by psychologists at the University of Bath in the UK. This study is the first to show that ADHD is more predictive of poor […]