Common food dye can trigger inflammatory bowel diseases, animal study suggests: Allura Red (also called FD&C Red 40 and Food Red 17), is a common ingredient in candies, soft drinks, dairy products and some cereals
Long-term consumption of Allura Red food dye can be a potential trigger of inflammatory bowel diseases (IBDs), Crohn’s disease and ulcerative colitis, says McMaster University’s Waliul Khan. Researchers using experimental animal models of IBD found that continual exposure to Allura Red AC harms gut health and promotes inflammation. The dye directly disrupts gut barrier function […]
Can a Healthy Lifestyle Prevent IBD?
Adopting and maintaining a healthy lifestyle may prevent inflammatory bowel disease (IBD), according to findings from an analysis of three prospective U.S. cohort studies, which were validated in three external European cohorts. In the primary analysis, maintaining low modifiable risk scores — based on risk factors including body mass index, smoking status, use of non-steroidal […]
IBD and Preterm Birth Risk; Leprosy Bacteria Promote Liver Growth; COVID and IBD
Histological inflammation and clinical disease activity in inflammatory bowel disease (IBD) were risk factors for preterm birth, especially in the case of ulcerative colitis. (eClinicalMedicine) Leprosy-causing bacteria (Mycobacterium leprae) promoted growth in healthy liver tissue in armadillos and may be able to help renew aging or injured livers. (Cell Reports Medicine) For older IBD patients […]
Dietary fiber is good for you, except when it’s not: Researchers uncover the role of dietary fiber and gut microbes in people with inflammatory bowel disease, a finding which could lead to personalized dietary guidelines
People who suffer from inflammatory bowel disease may soon have access to personalized dietary guidelines to keep them feeling well, thanks to new research on how dietary fibre affects the disease. The research team discovered that certain types of dietary fibre cause an inflammatory response in some patients, causing symptoms to worsen. They are now […]
Genotype Tied to Azathioprine Discontinuation for Toxicity
Patients with inflammatory conditions who have the CC genotype were at greater risk both for discontinuing the use of azathioprine (Imuran) due to hematopoietic toxicity and for needing to switch to lower doses, a retrospective cohort study found. In a competing-risk analysis involving over 1,400 such patients starting on azathioprine, those who carried the CC […]
When macrophages let off steam: Changes in cell metabolism protect macrophages from overloading and thus assist the resolution of inflammatory reactions
New data from a research team at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) shows how inflammatory reactions can be resolved by changes to the metabolism of macrophages. Danger signals released by damaged cells during inflammation play a role during this process. ‘Rewiring’ the mitochondria in the macrophages protects them against overloading and can thus improve the way in […]
Common IBD Meds Acquitted in Severe COVID Outcomes
Both biologics and mesalamine/sulfasalazine were not linked to severe COVID-19 outcomes in inflammatory bowel disease (IBD) patients, according to findings from the ongoing global SECURE-IBD trial. There was no association between mesalamine/sulfasalazine and adverse COVID outcomes. And when examining biologic-treated patients, there was no link between mesalamine/sulfasalazine use and either severe COVID-19 (adjusted odds ratio […]
Gene for sex hormone synthesis could play key role in eczema: Potential new treatment target for common skin condition
A study led by UT Southwestern dermatologists suggests that a common inflammatory skin condition may stem from poorly regulated sex hormones. The finding, published this week in PNAS, could offer an unexpected new target to fight this condition. Atopic dermatitis (AD) is a form of eczema. AD affects up to 13% of children and 10% […]
Ultra-processed food linked to higher risk of IBD: Further studies needed to identify contributory factors in processed foods that might account for these associations
A higher intake of ultra-processed food is associated with higher risk of inflammatory bowel disease (IBD), finds a study published by The BMJ today. Ultra-processed foods include packaged baked goods and snacks, fizzy drinks, sugary cereals, ready meals containing food additives, and reconstituted meat and fish products — often containing high levels of added sugar, […]
Cancer: Immunotherapies without side effects?
In recent years, immunotherapy has revolutionised the field of cancer treatment. However, inflammatory reactions in healthy tissues frequently trigger side effects that can be serious and lead to the permanent discontinuation of treatment. This toxicity is still poorly understood and is a major obstacle to the use of immunotherapy. Scientists from the University of Geneva […]