Ozanimod Controls MS Disease Activity Regardless of Age
WEST PALM BEACH, Fla. — Clinical and radiologic measures of disease activity remained stable or improved for relapsing multiple sclerosis (RMS) patients in all age groups over 7 to 8 years of continuous treatment with ozanimod (Zeposia). “Regardless of age category, the adjusted annualized relapse rate was below 0.2 in the phase III parent trials […]
PROs for Cutaneous Chronic GVHD After Transplant Tied to Disease Severity, Mortality
Skin-involved chronic graft-versus-host disease (cGVHD) had a significant association with long-term impairment of patient-reported outcomes (PROs), which also had a prognostic association with mortality, a multicenter prospective study showed. Patients with sclerotic cGVHD had significantly worse scores on a validated quality-of-life (QOL) instrument compared with those who had epidermal-type cGVHD. Patients with combination GVHD subtypes […]
Metabolic diseases may be driven by gut microbiome, loss of ovarian hormones
The gut microbiome interacts with the loss of female sex hormones to exacerbate metabolic disease, including weight gain, fat in the liver and the expression of genes linked with inflammation, researchers found in a new rodent study. The findings, published in the journal Gut Microbes, may shed light on why women are at significantly greater […]
Surgical Remission of Cushing’s Disease Tied to New Autoimmune Conditions
Development of autoimmune disease was more common in patients with surgical remission of Cushing’s disease than in those with surgically treated nonfunctioning pituitary adenomas (NFPAs), according to a retrospective matched cohort study. At 3 years after surgery, 10.4% of patients with Cushing’s disease developed new-onset autoimmune disease compared with 1.6% of those with NFPAs (HR […]
Physical activity is insufficient to counter cardiovascular risk associated with sugar-sweetened beverage consumption
Contrary to popular belief, the benefits of physical activity do not outweigh the risks of cardiovascular disease associated with drinking sugar-sweetened beverages, according to a new study led by Harvard T.?H.?Chan School of Public Health. Jean-Philippe Drouin-Chartier, professor at Université Laval’s Faculty of Pharmacy, was a co-author. Sugar-sweetened beverages are the largest source of added […]
CDC Report Indicates Teens Are Seeking To Escape Worries And Stress Through Drug Use
LOADINGERROR LOADING New research published by the Centers for Disease Control and Prevention (CDC) on Thursday indicates that teens with suspected substance abuse problems are turning to drugs to relax and for mental, emotional and physical relief. The report focused on 15,963 assessments from teens ages 13 to 18 and their responses to online questions […]
Erectile Dysfunction Drugs Tied to Less Alzheimer’s Risk
Erectile dysfunction drugs were associated with reduced risk of Alzheimer’s disease, electronic health record (EHR) data from 270,000 men in the U.K. suggested. Over a median follow-up of about 5 years, men who started taking phosphodiesterase type 5 (PDE5) inhibitors were less likely to have an Alzheimer’s diagnosis than nonusers (adjusted HR 0.82, 95% CI […]
Eliminating These 3 Foods From Your Diet Can Be A Game-Changer For Heart Health
Tom_Young67 via Getty Images Hint: All three foods are shown in this photo. Heart disease is the leading cause of death in the United States. People of most racial and ethnic groups in the country are more likely to die from a heart-related issue than anything else. These statistics are startling, and if you’ve ever […]
Potentially Protective Agent Shows Benefit in Niemann-Pick Type C
Patients with Niemann-Pick disease type C who received N-acetyl-L-leucine (NALL), an agent that potentially ameliorates lysosomal and metabolic dysfunction, showed reduced neurologic signs and symptoms after 3 months, a phase III crossover trial found. After 12 weeks of treatment, the mean change from baseline in scores on the Scale for the Assessment and Rating of […]
Alzheimer’s May Be Transmissible in Rare Circumstances
Alzheimer’s disease appeared to be transmissible under rare conditions, according to new research. Five patients treated with human growth hormone from cadaveric pituitary glands when they were children subsequently developed early dementia or biomarker changes consistent with Alzheimer’s disease, reported John Collinge, MD, of University College London in England, and co-authors in Nature Medicine. Four […]