Neuromodulation of the Peroneal Nerve Safe for Overactive Bladder
Electrical transcutaneous neuromodulation (eTNM) of the peroneal nerve led to fewer side effects compared with solifenacin (Vesicare) in the treatment of overactive bladder, a randomized trial showed. Among 76 treatment-naive women randomized 2:1 to peroneal eTNM or solifenacin, 12% versus 48% reported a treatment-related adverse event (TRAE; P<0.001), reported Jan Krhut, MD, PhD, of University […]
Maternal Mortality Rose Significantly in 2021, CDC Says
Maternal mortality in the U.S. significantly increased in 2021 compared with the previous year, the CDC reported Thursday. A total of 1,205 women died of maternal causes in 2021, compared with 861 in 2020 and 754 in 2019, according to the report from Donna Hoyert, PhD, of the CDC’s National Center for Health Statistics. The […]
Comorbidity Burden in People With HIV Tied to Increased Mortality Risk
The prevalence of comorbidities in people with HIV on effective antiretroviral treatment was consistently higher compared with HIV-negative individuals, and was linked to an increased risk for death, according to a prospective longitudinal cohort study. In people age 45 and older followed for a median 5.9 years, 5.2% of the 596 HIV-positive participants died compared […]
Childhood Adversity Tied to Race-Related Differences in Brain Development
Gray matter volume in key brain regions was lower in Black children compared with white children, likely due to disparities in childhood adversity, according to data from the Adolescent Brain Cognitive Development (ABCD) study. Among children ages 9 to 10 years, white kids showed greater gray matter volumes compared with Black kids in the amygdala, […]
Surgery Bests Endovascular Therapy for Most Limb-Threatening Ischemia Patients
CHICAGO — Surgical revascularization led to fewer major adverse limb events and deaths compared with endovascular therapy in patients with chronic limb-threatening ischemia, according to the prospective randomized BEST-CLI trial. After a median follow-up of 2.7 years, the primary composite outcome of major adverse limb events and death from any cause occurred in 42.6% of […]
Post-Op Pain Control More Challenging for Cannabis Users
NEW ORLEANS — Cannabis users reported somewhat worse postoperative pain compared with people who did not use cannabis before surgery, according to a large observational study. The difference was modest, however, as cannabis users had time-weighted average pain scores after surgery that were 0.58 higher on a scale from 0 to 10 (P<0.001), and they […]
Can We Protect Football Players From Head Injury?
American football continues to be the most popular sport in the U.S. As compared to combat sports such as boxing, concussive injuries to the brain in football occur accidentally when there is a head impact exposure (HIE) due to the player’s helmeted head encountering the opposing player(s) helmeted head, torso, or turf. Sub-concussive injuries are […]
If You Invite 455 People to Colonoscopy, You’ll Stop One Case of Cancer
Individuals invited to undergo screening colonoscopy had a lower risk of colorectal cancer compared with those who did not undergo screening, a European randomized trial found, though the reduction was lower than researchers had expected. In the Northern-European Initiative on Colorectal Cancer (NordICC) trial, an intention-to-screen analysis demonstrated that the risk of colorectal cancer at […]
Two Sides of Endosalpingiosis: Benign Growth or Harbinger of Cancer?
The ectopic endothelial abnormality endosalpingiosis doubled the likelihood of concurrent gynecologic malignancy as compared with endometriosis and conferred worse overall survival (OS), a retrospective case-control study showed. Among 515 patients with endosalpingiosis, 40.1% had concurrent cancer as compared with 18% of patients who had endometriosis. The significant association between endosalpingiosis and malignancy persisted after exclusion […]
Fewer Complications With Robotic Nephrectomy in Complex Kidney Tumors
Robotic-assisted partial nephrectomy (RAPN) led to a lower rate of complications compared with open partial nephrectomy (OPN) in patients with intermediate- or high-complexity kidney tumors, the randomized OpeRa trial found. Among over 200 patients, 36.6% of those who underwent RAPN had a postoperative complication of any kind within 30 days — the trial’s primary endpoint […]