Study Tests Office-Based Transperineal Approach to Prostate Biopsies
A multicenter randomized trial compared transperineal prostate biopsy without antibiotic prophylaxis versus transrectal biopsy with targeted prophylaxis, examining infections, prostate cancer detection, pain, and other measures. The findings were presented at the recent Genitourinary Cancers Symposium. In this exclusive MedPage Today video, investigator Jim C. Hu, MD, of Weill Cornell Medicine/NewYork-Presbyterian Hospital in New York […]
Umbilical Cord Milking in Non-Vigorous Infants Didn’t Impact Neurodevelopment
NATIONAL HARBOR, Md. — Compared to early cord clamping (ECC), umbilical cord milking (UCM) in non-vigorous infants had short-term benefits without any long-term adverse impacts on neurodevelopment, according to the cluster-randomized crossover MINVI trial. Among almost a thousand infants, those randomized to either UCM or ECC had comparable scores on the Ages and Stages Questionnaire, […]
Inequitable Treatment Persists Across Pediatric Specialties, Review Shows
Children in racial and ethnic minority groups received poorer healthcare services compared with white kids, a review of quantitative studies showed. Inequitable treatment persisted across pediatric specialties, including neonatology, primary care, emergency medicine, inpatient and critical care, surgery, developmental disabilities, mental health care, endocrinology, and palliative care, reported Nia Heard-Garris, MD, of Northwestern University’s Feinberg […]
Linezolid ‘Not Recommended’ to Treat Early Syphilis
Linezolid failed to meet noninferiority criteria when compared with standard benzathine penicillin G (BPG) in the treatment of early syphilis, according to findings of the randomized, controlled Trep-AB Study of cisgender men. Only 70% of trial participants with early syphilis who were treated with linezolid were cured, compared with 100% of participants treated with penicillin, […]
ASCT Tops CAR T-Cell Therapy for Relapsed LBCL in Complete Remission
SAN DIEGO — Autologous stem-cell transplantation (ASCT) led to improved outcomes as compared with CAR T-cell therapy for patients with relapsed large B-cell lymphoma (LBCL) in complete remission, a retrospective analysis showed. Patients who underwent ASCT had fewer relapses at 2 years (27.8% vs 48.0%) and better progression-free survival (PFS, 66.2% vs 47.8%), and overall […]
‘New Gold Standard’ for Previously Untreated CLL
SAN DIEGO — A time-limited, targeted combination significantly improved survival compared with chemoimmunotherapy in fit chronic lymphocytic leukemia (CLL) patients who met criteria for starting treatment, findings from the randomized FLAIR trial indicated. At 3 years, progression-free survival (PFS) rates reached 97% for patients randomized to venetoclax (Venclexta) plus ibrutinib (Imbruvica), as compared with 77% […]
Amoxicillin Alone for Acute Sinusitis Holds Up Against Broad-Spectrum Cousin
Treatment failure with amoxicillin-clavulanate for pediatric acute sinusitis was similar compared with amoxicillin alone, but the broad-spectrum antibiotic may be associated with more adverse events, an examination of a large commercial claims database revealed. The two frequently prescribed antibiotics were similar in their risk for treatment failure (1.7% with amoxicillin-clavulanate vs 1.8% with amoxicillin; RR […]
Cancer Patients More Likely to Die During COVID Pandemic
Cancer patients experienced significantly higher rates of COVID-19-related deaths compared with the general public, according to two retrospective studies from the U.S. and Canada. In a cross-sectional study published in JAMA Oncology, researchers found that the winter Omicron surge of 2021-2022 was particularly deadly, as the number of deaths among U.S. cancer patients increased by […]
An early breakfast may reduce the risk of developing type 2 diabetes: The study followed more than 100,000 participants in a French cohort for seven years
Eating breakfast after 9 a.m. increases the risk of developing type 2 diabetes by 59% compared to people who eat breakfast before 8 a.m. This is the main conclusion of a study in which ISGlobal, an institution supported by “la Caixa” Foundation, took part and which followed more than 100,000 participants in a French cohort. […]
Hemodiafiltration Reduced Dialysis Mortality in Kidney Failure
High-dose hemodiafiltration improved survival compared with standard hemodialysis for patients with kidney failure resulting in the need for kidney-replacement therapy, according to the randomized CONVINCE trial. High-dose hemodiafiltration cut all-cause mortality to 17.3% compared with 21.9% on conventional high-flux hemodialysis over a median 30 months of follow-up (HR 0.77, 95% CI 0.65-0.93), reported researchers led […]