Breast Cancer Overdiagnosis Risk May Be Substantial for Older Women
Older women screened for breast cancer were at a considerable risk of being overdiagnosed, according to a large retrospective cohort study. Researchers found that an estimated 31% of breast cancers among screened women from the ages of 70 and 74 were potentially overdiagnosed, reported Ilana Richman, MD, MHS, of the Yale School of Medicine in […]
AI-Backed Mammography Keeps Up With Docs for Cancer Detection
Artificial intelligence-supported mammography resulted in a cancer detection rate comparable to that of two breast radiologists working together, while also substantially cutting screening workload. Among more than 80,000 women randomized to either AI-supported mammography screening or to standard double reading without AI, cancer detection rates were 6.1 (95% CI 5.4-6.9) per 1,000 screened participants in […]
ACP Sticks With Age 50 for Colorectal Cancer Screening
The American College of Physicians (ACP) updated guidance reaffirming its stance that colorectal cancer screening should wait until age 50 for average-risk, asymptomatic adults. The ACP recommends that clinicians “should discuss the uncertainty around benefits and harms of screening” with individuals ages 45 to 49, and that screening be dropped in asymptomatic average-risk adults older […]
Transplant May Be Reasonable for Certain CRC Patients With Liver Mets
For a select group of patients with colorectal cancer and unresectable liver metastases, liver transplant may be a reasonable option, according to results from a prospective, nonrandomized controlled cohort study. Overall, among 61 patients who underwent liver transplant, the median disease-free survival (DFS) was 11.8 months (95% CI 9.3-14.2), with a 5-year DFS rate of […]
MR-Guided Adaptive SBRT Tied to Reduced Side Effects in Prostate Cancer
Magnetic resonance (MR)‐guided adaptive stereotactic body radiotherapy (SBRT) for prostate cancer was associated with significantly lower rates of acute genitourinary and gastrointestinal toxicities compared with CT-guided non-adaptive SBRT, according to a systematic review and meta-analysis. Across 29 prospective studies involving over 2,500 patients, the risk of short‐term genitourinary side effects was reduced by 44% with […]
Primary Surgery Vs Radiation in Oropharyngeal Cancer: Does One Come Out a Winner?
MONTREAL — A study that looked at surgery versus radiation therapy (RT) for oropharyngeal cancer treatment found pros and cons with both approaches, but ultimately, surgery seemed to be the better bet. Patients with T1-T2 oropharyngeal squamous cell carcinoma (OPSCC) in a database underwent primary transoral robotic surgery (TORS) versus primary RT and/or chemoRT (RT/CRT), […]
IMRT Dosing Strategy Eases Dysphagia in Head and Neck Cancer
In patients with head and neck cancer, a strategy to reduce the radiation dose to dysphagia-and aspiration-related structures improved swallowing and other functional outcomes compared with standard intensity-modulated radiotherapy (IMRT), according to results from the phase III DARS trial. Patients treated with dysphagia-optimized (DO) IMRT had significantly higher patient-reported composite scores on the MD Anderson […]
EphrinB2 Expression in Urothelial Cancer Tied to Checkpoint Inhibitor Activity
A prior analysis of data from The Cancer Genome Atlas (TCGA) demonstrated that high EphrinB2 gene expression was associated with poor survival in patients with muscle-invasive bladder cancer. At the American Society of Clinical Oncology (ASCO) annual meeting, researchers reported new findings showing that EphrinB2 expression in patients with metastatic urothelial carcinoma was linked with […]
Agent Orange Exposure Tied to Bladder Cancer Risk in Veterans
Exposure to Agent Orange was associated with a modestly increased risk of bladder cancer among Vietnam War veterans, according to a retrospective cohort study. Among over 2.5 million male veterans, exposure to Agent Orange was associated with a relative 4% higher risk of bladder cancer (HR 1.04, 95% CI 1.02-1.06, P<0.001), reported Stephen Williams, MD, […]
Breast Cancer Recurrence Risk Varies by Molecular Subtype
Different molecular subtypes of breast cancer had varying rates and patterns of recurrence following surgery for early-stage disease, a large retrospective cohort study showed. Overall, the 10-year freedom from ipsilateral, regional, and contralateral recurrence was 95.9%, 96.1%, and 96.5%, respectively. Using hormone receptor (HR)-positive (+)/HER2-negative (-) tumors as the reference, HR-/HER2+ breast cancer had the […]