Study Tests Office-Based Transperineal Approach to Prostate Biopsies
A multicenter randomized trial compared transperineal prostate biopsy without antibiotic prophylaxis versus transrectal biopsy with targeted prophylaxis, examining infections, prostate cancer detection, pain, and other measures. The findings were presented at the recent Genitourinary Cancers Symposium. In this exclusive MedPage Today video, investigator Jim C. Hu, MD, of Weill Cornell Medicine/NewYork-Presbyterian Hospital in New York […]
Study Backs Recommended Antibiotic Approach for Aspiration Pneumonia
Antibiotic therapy with extended anaerobic coverage (EAC) was not associated with a survival benefit in patients with community-acquired aspiration pneumonia, according to results from a retrospective cohort study that support current guidelines. Across 18 hospitals in Canada, in-hospital mortality rates were 30.3% for patients treated with antibiotic therapy with limited anaerobic coverage (LAC) and 32.1% […]
Study: Let’s Revisit Extended Antibiotic Prophylaxis in Joint Replacement
SAN FRANCISCO — Routinely giving antibiotic prophylaxis for 10 days in arthroplasty patients apparently did nothing beyond what was achieved with shorter protocols to prevent prosthetic joint infections (PJIs) at one major medical center. PJI rates at Vanderbilt University Medical Center in Nashville were no lower after a policy was implemented in 2020 to provide […]
Novel Oral Antibiotic Effective Against Uncomplicated UTIs
Gepotidacin — a first-in-class oral antibiotic — appeared effective and safe for the treatment of uncomplicated urinary tract infections (UTIs) in a pair of large, phase III non-inferiority studies. In the two trials — EAGLE-2 and EAGLE-3 — the therapy was shown to be noninferior to nitrofurantoin, an antibiotic commonly used as a first-line therapy […]
Add-On Clarithromycin Pans Out in Community-Acquired Pneumonia Trial
In a phase III trial, the addition of oral clarithromycin to beta-lactam antibiotic treatment improved the clinical response of people with community-acquired pneumonia who had systemic inflammatory response syndrome, findings that support existing guidelines. In the study, the proportion of patients meeting the primary composite endpoint after 72 hours of treatment — fulfilling criteria for […]
Shorter Antibiotic Course Noninferior for UTI Recurrence in Kids
Five days of oral antibiotic treatment for febrile urinary tract infections (UTIs) in kids was noninferior to the standard 10-day course, the randomized controlled STOP trial showed. The recurrence rate of all UTIs — febrile and non-febrile — within 30 days of treatment with oral amoxicillin-clavulanate acid was 2.8% in the short-term group compared with […]
Eosinophilic Esophagitis Risk Linked to Medications in Pregnancy, Infancy
Antibiotic and acid suppressant exposure during the perinatal period was linked to the development of eosinophilic esophagitis (EoE) later in life, a Danish cohort study found. Infants with any antibiotic use had a 40% greater risk of developing EoE later in childhood compared to matched controls without such exposure (adjusted OR 1.4, 95% CI 1.1-1.7), […]
Inhaled Antibiotic Cuts Risk of Ventilator-Associated Pneumonia
A short course of an inhaled antibiotic helped prevent the incidence of ventilator-associated pneumonia in the intensive care unit (ICU), a randomized trial in France showed. In critically ill patients intubated for between 3 to 4 days, administration of amikacin (Arikayce) reduced the rate of first ventilator-associated pneumonia compared with an inhaled placebo (15% vs […]
Shorter Antibiotic Course Not as Effective for Children With UTIs
Abbreviated antibiotic treatment didn’t measure up for children with urinary tract infection (UTI), the SCOUT trial found. Stopping antibiotics when symptoms improved after an initial 5-day course yielded a 4.1% rate of persistent symptomatic UTI by follow-up at day 11-14 compared with 0.6% when kids had the full 10-day course, Nader Shaikh, MD, MPH, of […]
Sutezolid With 3-Drug Combo Appears Safe and Effective in Multidrug-Resistant TB
SEATTLE — Adding the oxazolidinone antibiotic sutezolid to a three-drug combination appeared to be safe and effective for people with multidrug-resistant tuberculosis (TB), according to a dose-finding phase II study. Across five treatment arms that included four different doses of sutezolid with bedaquiline, delamanid, and moxifloxacin at standard doses, there was a similar increase in […]