FDA Advisors Endorse Rexulti for Agitation in Alzheimer’s Dementia
FDA advisors voted in favor of brexpiprazole (Rexulti) for treating agitation associated with Alzheimer’s dementia (AAD), despite increased mortality risk. By a vote of 9-1 on Friday, members of the agency’s Psychopharmacologic Drugs Advisory Committee (PDAC) and the Peripheral and Central Nervous System Drugs Advisory Committee (PCNS) said the data presented by the drug’s sponsors, […]
Autopsies Show Relationship Between Alzheimer’s Pathology and Diet in Older Adults
Healthy, plant-based dietary patterns were linked with less postmortem Alzheimer’s disease pathology, primarily beta-amyloid load, in older adults. Both MIND diet scores (β -0.022, P=0.035; standardized beta -2.0) and Mediterranean diet scores (β -0.007, P=0.039; standardized beta -2.3) were significantly associated with lower global Alzheimer’s pathology, reported Puja Agarwal, PhD, of Rush University in Chicago, […]
Opinion | There’s No ‘Recipe’ to Reduce Dementia Risk — Yet
Numbers don’t lie — dementia is a global health crisis. According to Alzheimer’s Disease International, dementia impacts more than 55 million individuals worldwide, and there are over 10 million new cases each year. In the U.S. alone, more than 6 million people are living with Alzheimer’s. Because dementia impacts not only the person with the […]
Alzheimer’s Drug Lecanemab Wins FDA Approval
Lecanemab (Leqembi) was approved under the accelerated approval pathway to treat Alzheimer’s disease, the FDA announced on Friday. The anti-amyloid should be started only in patients with mild cognitive impairment or who are at the mild dementia stage of Alzheimer’s disease, the population studied in clinical trials, the agency noted, and the drug label indicates […]
Scattered Brain Bleeds, Vasculitis in Alzheimer’s Trial Death
A fatal bleeding event in an Alzheimer’s clinical trial participant may have been linked with the investigational anti-amyloid agent lecanemab, a case report suggested. However, drug trialists are not willing to assign blame yet, especially as lecanemab’s fate hangs in a potential FDA approval for early Alzheimer’s disease later this week. Information about the case […]
Congressional Probe of Alzheimer’s Drug Approval Finds Fault With FDA Actions
The FDA broke with its own protocols in reviewing and subsequently approving Alzheimer’s drug aducanumab (Aduhelm), by inappropriately collaborating with drugmaker Biogen on briefing documents, holding unreported meetings, and failing to gain internal consensus before engaging in such collaborations, according to an in-depth congressional investigation of the interactions between the agency and the drugmaker. The […]
Fasting-mimicking diet reduces signs of dementia in mice
Cycles of a diet that mimics fasting appear to reduce signs of Alzheimer’s in mice genetically engineered to develop the illness, according to a new USC Leonard Davis School of Gerontology-led study. The study appeared in Cell Reports on Sept. 27. The researchers, led by Professor Valter Longo in collaboration with Professors Christian Pike and […]
Doctors May Have Found A Way To Reduce The Effects Of Alzheimer’s
A ‘pacemaker’ for the brain has helped a number of Alzheimer’s patients regain some of the cognitive function that they had previously lost because of the disease. The process involves placing tiny electrical wires deep within the frontal lobes of the brain and then applying a small electrical current.
Brain Zaps Give Month-Long Memory Boost – MedicineNet Health News
Latest Alzheimer’s News By Denise Mann HealthDay Reporter TUESDAY, Aug. 23, 2022 If you’re a senior who struggles to remember where you put your car keys, could noninvasive brain stimulation boost your memory? Yes, claims a new study that found folks who were treated with transcranial alternating current stimulation for four days in a row […]
Diets Heavy in ‘Ultra-Processed’ Foods Could Harm the Brain
Latest Alzheimer’s News By Steven Reinberg HealthDay Reporter THURSDAY, July 28, 2022 (HealthDay News) Eating lots of ultra-processed foods may dramatically increase your risk for dementia, according to a new study by researchers in China. Ultra-processed foods are high in sugar, fat and salt, but low in protein and fiber. Sodas, salty and sugary snacks […]