Alzheimer’s Association, IDPH launch initiative to potentially reduce cognitive decline
The Alzheimer’s Association Illinois Chapter recently announced it will partner with the state’s Department of Public Health and other stakeholders on a new initiative to reduce cognitive decline through lifestyle-based education and outreach.
Alzheimer’s Biomarkers Common in People With Other Dementias
Alzheimer’s pathology was common in other dementias. An Alzheimer’s biomarker profile was seen in unspecified dementia, Parkinson’s dementia, and frontotemporal dementia. Biomarkers indicating Alzheimer’s-like pathology were tied to cognitive function. Alzheimer’s disease pathology was common in people diagnosed with other dementias, a large cross-sectional study in Sweden showed. While most patients clinically diagnosed with Alzheimer’s […]
Is Alzheimer’s Transmissible Through Bone Marrow Cells?
A mouse experiment suggested familial Alzheimer’s disease may be transmitted through bone marrow stem cells, but the implications of the findings were limited. The research involved transplanting bone marrow stem cells from mice engineered to carry a familial Alzheimer’s disease mutation into healthy mice, which led to “rapid development of Alzheimer’s disease pathological hallmarks,” reported […]
Erectile Dysfunction Drugs Tied to Less Alzheimer’s Risk
Erectile dysfunction drugs were associated with reduced risk of Alzheimer’s disease, electronic health record (EHR) data from 270,000 men in the U.K. suggested. Over a median follow-up of about 5 years, men who started taking phosphodiesterase type 5 (PDE5) inhibitors were less likely to have an Alzheimer’s diagnosis than nonusers (adjusted HR 0.82, 95% CI […]
Alzheimer’s May Be Transmissible in Rare Circumstances
Alzheimer’s disease appeared to be transmissible under rare conditions, according to new research. Five patients treated with human growth hormone from cadaveric pituitary glands when they were children subsequently developed early dementia or biomarker changes consistent with Alzheimer’s disease, reported John Collinge, MD, of University College London in England, and co-authors in Nature Medicine. Four […]
Handheld Device Detects Alzheimer’s Biomarkers; Long COVID Smell Loss; MS Fatigue
A handheld wireless device using a graphene field-effect transistor sensor detected Alzheimer’s and Parkinson’s biomarkers amyloid beta, tau, and alpha-synuclein. (Proceedings of the National Academy of Sciences) Whistleblowers suggested that a University of Southern California neuroscientist may have manipulated data that supported a major stroke trial and blood-brain barrier research. (Science) Loss of smell and […]
Few Early Alzheimer’s Patients Qualify for Lecanemab
Few people with early Alzheimer’s disease met eligibility criteria for the new anti-amyloid monoclonal antibody treatments lecanemab (Leqembi) and aducanumab (Aduhelm), cross-sectional data from the Mayo Clinic Study of Aging showed. Of 237 people with mild cognitive impairment or mild dementia and increased brain amyloid on PET, clinical trial inclusion and exclusion criteria narrowed the […]
Alzheimer’s Drug Wins Full FDA Approval
Lecanemab (Leqembi) became the first Alzheimer’s treatment targeted at the disease process to win full FDA approval, the agency announced today. “Today’s action is the first verification that a drug targeting the underlying disease process of Alzheimer’s disease has shown clinical benefit in this devastating disease,” said Teresa Buracchio, MD, acting director of the Office […]
Alzheimer’s Progression Delayed by Rare Genetic Variant
The world’s second case of ascertained extreme resilience to autosomal dominant Alzheimer’s disease was reported, suggesting a new way Alzheimer’s progression might be delayed. A rare genetic variant of RELN, which encodes the signaling protein reelin, was associated with 20 years of resilience to autosomal dominant Alzheimer’s disease in a Colombian man, reported Diego Sepulveda-Falla, […]
Opinion | AI Offers Hope for Those With Alzheimer’s Disease
According to the CDC, as of 2020, approximately 5.8 million people in the U.S. were living with Alzheimer’s disease. The prevalence of this disease is expected to continue to rise as the population ages. The number of people living with the disease is projected to grow three-fold, to 14 million, by 2060. While there is […]