Novel Triple Agonist Nabs Biggest Weight Loss Yet in Obesity Trial
SAN DIEGO — An investigational triple-hormone receptor agonist yielded major weight loss in people with obesity, a phase II trial showed. By 24 weeks, patients on any of the four doses of once-weekly injectable retatrutide lost a significantly greater amount of weight than those on placebo — achieving the trial’s primary endpoint — reported Ania […]
Second-Line CAR-T Impresses in Transplant-Ineligible Large B-Cell Lymphoma
Treatment with second-line lisocabtagene maraleucel (liso-cel; Breyanzi) yielded a response rate of 80% for patients with relapsed or refractory large B-cell lymphoma (LBCL) who were not candidates for hematopoietic stem cell transplant, the phase II PILOT study showed. Among 61 evaluable patients with PET-positive disease, 54% achieved a complete response with the chimeric antigen receptor […]
New treasure trove of globular clusters holds clues about galaxy evolution
A survey completed using a combination of ground and space-based telescopes yielded a treasure trove of previously unknown globular clusters — old, dense groups of thousands of stars that all formed at the same time — in the outer regions of the elliptical galaxy Centaurus A. The work presents a significant advance in understanding the […]