Raludotatug Deruxtecan Promising in Platinum-Resistant Advanced Ovarian Cancer
SAN DIEGO — Treatment with raludotatug deruxtecan (R-DXd) led to an “exciting” response rate among patients with heavily pretreated, platinum-resistant advanced ovarian cancer, according to an early-phase trial. In a subgroup analysis of the first-in-human phase I study, there was one complete response and 17 partial responses among 37 evaluable patients treated with R-DXd, an […]
FDA Approves First-Ever Drug for Serious Liver Condition
The FDA granted accelerated approval to resmetirom (Rezdiffra) as the first treatment for adults with noncirrhotic non-alcoholic steatohepatitis (NASH), also now referred to as metabolic dysfunction-associated steatohepatitis (MASH). A once-daily oral agent, resmetirom is a liver-directed thyroid hormone receptor (THR)-β selective agonist designed to target key underlying causes of NASH; the drug is specifically indicated […]
A healthier diet is linked with a slower pace of aging, reduced dementia risk, study shows
A healthier diet is associated with a reduced dementia risk and slower pace of aging, according to a new study at Columbia University Mailman School of Public Health and The Robert Butler Columbia Aging Center. The findings show that a diet-dementia association was at least partially facilitated by multi-system processes of aging. While literature had […]
Olivia Munn Shares Breast Cancer Diagnosis, Reveals Medical Decision That Saved Her Life
LOADINGERROR LOADING Olivia Munn has undergone a double mastectomy after being diagnosed with an aggressive form of breast cancer. The actor, 43, detailed her path to diagnosis in an emotional Instagram post on Tuesday, which included photos from the hospital and a raw written statement. Advertisement “I hope by sharing this it will help others […]
Most People With TB Report No Persistent Cough
A significant proportion of people in the community with pulmonary tuberculosis (TB) have subclinical disease, according to a meta-analysis involving survey studies across Africa and Asia. In adjusted analyses, 82.8% (95% CI 78.6-86.6) of participants with TB reported no persistent cough and 62.5% (95% CI 56.6-68.7) reported no cough at all, according to Frank Cobelens, […]
Beyond Kegels: Brittany Mahomes’ Pelvic Floor Woes Post-Childbirth
Welcome to Culture Clinic, MedPage Today‘s collaboration with Northwell Health to offer a healthcare professional’s take on the latest viral medical topics. Brittany Mahomes, influencer and businesswoman, is married to her high school sweetheart Patrick Mahomes — the Kansas City Chiefs’ star quarterback who recently took home his third Superbowl win. Their daughter was born […]
Semaglutide Cuts Liver Disease Severity in People With HIV
DENVER — Semaglutide (Ozempic) reduced the amount of liver fat by nearly a third in people with HIV and metabolic dysfunction-associated steatotic liver disease (MASLD), the open-label phase IIb SLIM LIVER study showed. In the single-arm trial, the absolute change in intrahepatic triglyceride (IHTG) content across all participants was -4.2% (95% CI -5.4 to -3.1, […]
‘Vampire Facials’ at Spa Linked to HIV Infections
DENVER — Five cases of HIV infection associated with cosmetic platelet-rich plasma (PRP) microneedling, known as a “vampire facial,” were linked to one spa in New Mexico, according to a report from CDC investigators. From 2018 to 2023, four former clients of the spa and one sexual partner of a client were diagnosed with HIV, […]
Interventions Can Reduce CVD Risk Factors in HIV Patients, Studies Show
DENVER — Efforts aimed at lowering blood pressure (BP) and cholesterol in people with HIV can succeed, two randomized trials presented here demonstrated. In the first, prehypertensive Haitians on stable antiretroviral therapy (ART) who received early treatment with a calcium channel blocker experienced significantly greater reductions in systolic and diastolic BP compared with those who […]
First-Line Nivolumab Plus Chemo Approved for Bladder Cancer
The FDA approved the PD-1 immune checkpoint inhibitor nivolumab (Opdivo) in combination with cisplatin and gemcitabine for the first-line treatment of adults with unresectable or metastatic urothelial carcinoma, the agency announced Thursday. Approval was based on results from the phase III CheckMate-901 trial, which were presented last year at the European Society for Medical Oncology […]