Opinion | Ode to the Paper Chart
Oh how I miss the feel of your thick spine, so wide I could barely grasp you with my oddly small hands. Wrist cocked, an awkward drag ensued from rack to desk, your heft landing with a thump under fluorescent lights on the laminate desk. I scooted into the low chair and dove in with […]
Habitually Checking Social Media May Be Linked to Preteen Brain Changes
Habitually checking social media may be associated with changes in the brain’s sensitivity to social rewards and punishments in preteens, according to an imaging-based study. Young adolescents who checked in to Facebook, Instagram, or Snapchat at least 15 times per day also showed distinct longitudinal changes in their functional brain development, reported Eva H. Telzer, […]
Ashton Kutcher’s Autoimmune Vasculitis
In a clip from an episode of the Paramount+ docuseries “The Checkup: With Dr. David Agus” actor Ashton Kutcher talks about a previous health struggle. About 3 years ago, the “That ’70s Show” star “woke up one day and was having vision issues [and] could hardly see,” he said. “[It] knocked out my hearing, which […]
Congressional Probe of Alzheimer’s Drug Approval Finds Fault With FDA Actions
The FDA broke with its own protocols in reviewing and subsequently approving Alzheimer’s drug aducanumab (Aduhelm), by inappropriately collaborating with drugmaker Biogen on briefing documents, holding unreported meetings, and failing to gain internal consensus before engaging in such collaborations, according to an in-depth congressional investigation of the interactions between the agency and the drugmaker. The […]
11 New Year’s Resolutions That Can Actually Improve Your Health
The new year is approaching, which for many signifies a fresh start with a set of resolutions ― including ones that aim to improve well-being. But people often default to “losing weight,” believing that shedding pounds is the only way to achieve optimal health. Not only is this a vague goal; it frequently comes with […]
Families Push Research Forward in Rare Diseases
This story was supported by a grant from the National Press Foundation in partnership with Fondation de France. For the main story on how mRNA is being investigated for its potential in rare diseases, click here. Kathy Stagni first met Charles Venditti, MD, PhD, at a meeting of her organization, the Organic Acidemia Association, more […]
COVID Vaccines Made mRNA a Household Name. How Can It Help in Rare Diseases?
This story was supported by a grant from the National Press Foundation in partnership with Fondation de France. For MedPage Today‘s related story on how families support rare disease research, click here. One of the hardest things about managing Jordan Franks’ propionic acidemia (PA) was feeding him. Jordan never wanted to eat. His body seemed […]
Novel Capsid Inhibitor Approved for Super-Refractory HIV
The FDA approved lenacapavir (Sunlenca) in combination with antiretroviral therapy (ART) for heavily pretreated HIV-1 patients with drug-resistant infections, and for those who cannot tolerate other available options. Lenacapavir, a first-in-class long-acting HIV capsid inhibitor, is initially administered via oral tablets (300 mg) and subcutaneous shots (463.5 mg/1.5 mL), which are then followed by maintenance […]
Adagrasib Shows Anti-Tumor Activity in Heavily Pretreated KRAS-Mutant CRC
Adagrasib (Krazati) demonstrated antitumor activity in heavily pretreated patients with KRAS G12C-mutated, metastatic colorectal cancer (CRC), according to phase I/II study results. Monotherapy with the oral KRAS inhibitor led to responses in 19% (95% CI 8-33) of 43 evaluable patients with CRC, with a median duration of response of 4.3 months (95% CI 2.3-8.3) and […]
Metformin Protective Against Joint Replacement in Type 2 Diabetes
Among people with type 2 diabetes, use of metformin might help to stave off total joint replacement, a population-based cohort study showed. Among over 40,000 patients, daily metformin was associated with a 30% lower risk for total knee and hip replacement compared with no metformin (adjusted HR 0.70, 95% CI 0.60-0.81) over a median follow-up […]