Molecular imaging identifies brain changes in response to food cues; offers insight into obesity interventions
Molecular imaging with 18F-flubatine PET/MRI has shown that neuroreceptors in the brains of individuals with obesity respond differently to food cues than those in normal-weight individuals, making the neuroreceptors a prime target for obesity treatments and therapy. This research, presented at the Society of Nuclear Medicine and Molecular Imaging 2023 Annual Meeting, contributes to the […]
Dolutegravir Switch Maintains Second-Line HIV Suppression
Switching people living with HIV from a ritonavir-boosted protease inhibitor (PI) to a dolutegravir (Tivicay)-based regimen maintained viral suppression just as well, according to a randomized trial out of Kenya. Among a cohort of nearly 800 participants, 5.0% who switched to dolutegravir and 5.1% who continued taking a ritonavir-boosted PI had a plasma HIV type […]
Shorter Antibiotic Course Not as Effective for Children With UTIs
Abbreviated antibiotic treatment didn’t measure up for children with urinary tract infection (UTI), the SCOUT trial found. Stopping antibiotics when symptoms improved after an initial 5-day course yielded a 4.1% rate of persistent symptomatic UTI by follow-up at day 11-14 compared with 0.6% when kids had the full 10-day course, Nader Shaikh, MD, MPH, of […]
Near 15% Weight Loss With Novel Oral GLP-1 RA in Phase II Obesity Trial
SAN DIEGO — Orforglipron, an investigational nonpeptide GLP-1 receptor agonist, helped people with obesity lose a significant amount of weight in a phase II trial. Tested at four once-daily doses — 12, 24, 36, or 45 mg — patients on orforglipron lost between 8.6% to 12.6% of body weight compared with a 2% change seen […]
IG Live June 27: The Evolving Landscape of Gender-Affirming Care
The state of gender-affirming care is constantly evolving, with restrictions and bans on the provision of care continuing to spread across the country. As of June 12, a total of 20 states have restrictions on gender-affirming care for youth. During Pride Month, experts will discuss how healthcare professionals can best support gender diverse patient populations […]
Omega-3 fatty acids linked to slower decline in ALS
People with amyotrophic lateral sclerosis (ALS) who eat more foods high in certain omega-3 fatty acids like flaxseed oil, walnuts, canola oil and pumpkin seeds may have a slower physical decline from the disease and may have a slightly extended survival. The study, which looked at the survival of people with ALS over the course […]
Trial Suggests Optimal Approach to Unresectable CRC Liver Mets
For patients with initially unresectable colorectal cancer liver metastases, FOLFOXIRI plus bevacizumab (Avastin) was the “preferred” systemic induction regimen for those with a right-sided or RAS- or BRAF V600E-mutated primary tumor, according to a phase III randomized trial. Among these patients, the median progression-free survival (PFS) was 9.0 months in those receiving FOLFOX or FOLFIRI […]
Are Athletes With T1D Putting Themselves at Risk for Recurrent Hypoglycemia?
CHICAGO – Nearly three-fourths of people with type 1 diabetes (T1D) who engaged in aerobic activity failed to follow guidelines for preventing hypoglycemia, according to a survey-based study. Guidelines state that if a person with T1D experiences severe hypoglycemia, they should not exercise for 24 hours, but 73% of those surveyed (n=102 adults) reported exercising […]
Hemodiafiltration Reduced Dialysis Mortality in Kidney Failure
High-dose hemodiafiltration improved survival compared with standard hemodialysis for patients with kidney failure resulting in the need for kidney-replacement therapy, according to the randomized CONVINCE trial. High-dose hemodiafiltration cut all-cause mortality to 17.3% compared with 21.9% on conventional high-flux hemodialysis over a median 30 months of follow-up (HR 0.77, 95% CI 0.65-0.93), reported researchers led […]
What To Do If Family Members Make Homophobic Comments
Maskot via Getty Images Psychologists share the six ways you can deal with hurtful comments in a homophobic household. Generally, most adults will have conflicts with their parents at some point in their lives. However, people in the LGBTQ+ community can face additional issues if their family members aren’t accepting of their sexuality or gender […]