Adcetris Plus Chemo Effective in HIV-Related Hodgkin Lymphoma
Brentuximab vedotin (Adcetris) in combination with doxorubicin, vinblastine, and dacarbazine (AVD) was effective for patients with HIV-related stages II-IV classical Hodgkin lymphoma (cHL), according to results from the phase I/II AMC-085 study. All 37 patients who completed therapy in the 41-patient trial achieved a complete response; at 2 years, the progression-free survival (PFS) rate reached […]
Neurodevelopment After Prenatal Exposure to Newer Epilepsy Drugs Tracked for 3 Years
Children with fetal exposure to newer antiseizure medications showed no difference in neurodevelopmental outcomes at age 3 compared with unexposed children, data from the ongoing MONEAD study showed. In the prospective observational study, mean verbal index scores at age 3 did not differ for children of women with epilepsy (102.7) versus those born to mothers […]
Surveillance Still Not an Option for Many With Subsegmental Pulmonary Embolism
Only a narrow pool of outpatients with acute subsegmental pulmonary embolism (PE) may be candidates for structured surveillance without anticoagulation based on current guideline restrictions, a retrospective study found. At one large integrated health system, only one person out of 229 low-risk adults received structured surveillance for subsegmental PE — a “remarkably low” 0.4% over […]
Study Questions Relationship Between Hospital Competition and Surgical Quality
Outcomes after high-risk elective surgery did not have a clear relationship with a hospital’s local competitive landscape, a study using nationally representative Medicare data suggested. Hospitals in the highest-competition U.S. markets had mixed postsurgical outcomes compared with those in the lowest-competition markets: risk-adjusted 30-day mortality was lower for pancreatectomy (OR 0.93, 95% CI 0.91-0.95), rectal […]
Irregular sleep patterns associated with harmful gut bacteria
New research has found irregular sleep patterns are associated with harmful bacteria in your gut. The study, published today in The European Journal of Nutrition, by researchers from King’s College London and ZOE, the personalised nutrition company, is the first to find multiple associations between social jet lag — the shift in your internal body […]
Drinking kombucha may reduce blood sugar levels in people with type-two diabetes: Small pilot study suggests larger trials warranted to confirm potential benefit of fermented tea
People with type-II diabetes who drank the fermented tea drink kombucha for four weeks had lower fasting blood glucose levels compared to when they consumed a similar-tasting placebo beverage, according to results from a clinical trial conducted by researchers at Georgetown University’s School of Health, the University of Nebraska-Lincoln and MedStar Health. This finding, from […]
Success With HIV-to-HIV Kidney Transplants
Three people living with HIV had promising outcomes after donating kidneys to three others with HIV, according to a prospective study within the HOPE in Action Multicenter Consortium. Among the three living donors, grade 3 or higher nephrectomy-related adverse events occurred in two donors after donation, including a medically managed ileus and a laparoscopically repaired […]
Adjuvant Everolimus Falls Short in High-Risk Renal Cancer
Adjuvant everolimus (Afinitor) failed to significantly improve recurrence-free survival (RFS) in patients with renal cell carcinoma (RCC) who were at high risk for recurrence after nephrectomy, according to results from a randomized phase III trial. The so-called EVEREST study showed that among 1,545 patients with histologically confirmed RCC who had undergone a full surgical resection, […]
Kombucha Shows Potential Diabetes Benefit in Small Trial
Drinking kombucha helped improve blood glucose levels in people with type 2 diabetes, according to a randomized, controlled pilot trial. After drinking the fermented tea for a month, participants saw a significant reduction in average fasting blood glucose levels (164 vs 116 mg/dL, P=0.035) not seen in those in the placebo group (162 vs 141 […]
Pegcetacoplan-Related Eye Inflammation: The Search Is on for Answers
SEATTLE — Reports of unexpected panuveitis and retinal occlusive vascular disease associated with pegcetacoplan (Syfovre) treatment has triggered a search for answers by ophthalmologists and the drug’s manufacturer. Since July 3, the American Society of Retina Specialists (ASRS) Research and Safety in Therapeutics (ReST) Committee has learned of seven cases of retinal inflammation and vascular […]