Inside CDC, Shooting Adds to Trauma as Workers Describe Projects, Careers in Limbo
CDC workers whose jobs have been reinstated after dizzying Trump administration disruptions say they remain stuck in a budgetary, political, and professional limbo. Their work includes major agency priorities such as HIV testing and monitoring, as well as work at the nation’s leading sexually transmitted infections lab. And while employees are back, many projects have […]
Cabozantinib Plus Atezolizumab Delays Progression in mCRPC
SAN FRANCISCO — In patients with metastatic castration-resistant prostate cancer (mCRPC) whose disease progressed on a novel hormonal therapy, the combination of cabozantinib (Cabometyx) plus atezolizumab (Tecentriq) improved radiographic progression-free survival (rPFS) versus a switch to a second hormonal agent, a phase III trial showed. The so-called CONTACT-02 study included patients with extrapelvic nodal or […]
When Women’s Fertility Begins and Ends Seems Important for RA Development
British women whose capability of bearing children either started late or ended early — naturally or otherwise — were at increased risk for developing rheumatoid arthritis (RA), compared with women with earlier menarche or later menopause, researchers found. In an analysis of more than 220,000 female participants in the U.K. Biobank project, those with menarche […]
Excess calories during development alters the brain and spurs adult overeating
People whose mothers are overweight during pregnancy and nursing may become obese as adults because early overnutrition rewires developing brains to crave unhealthy food, according to a Rutgers study in Molecular Metabolism. Rutgers researchers traced this link from mother to child in mice with an experiment that began by letting some mice get obese on […]
Opinion | Medical Education Has ‘Gone Woke’ — That’s a Good Thing
A Black woman whose kidneys only function at 15% of normal wishes to be evaluated for a kidney transplant. Although this is very reasonable, before 2021, many physicians would have said, “I’m sorry, but your kidney function is not bad enough to be referred for a transplant.” This is because the kidney function calculator used […]
Targeted drug achieves 43% response rate in KRAS-mutated lung cancer: Experimental drug adagrasib also shows activity in lung cancer metastases to the brain
Nearly 43% of patients with non-small cell lung cancer (NSCLC) whose lung cancers harbored a specific KRAS mutation responded to the experimental drug adagrasib, and the targeted agent also showed activity against lesions in the brain that metastasized from the lung tumors, according to results of a study led by Dana-Farber Cancer Institute investigators. Mutations […]
Investigational RSV Vaccine in Pregnancy Tied to Fewer Abx Scripts for Babies
Infants whose mothers received an investigational respiratory syncytial virus (RSV) vaccine in pregnancy had fewer antimicrobial prescriptions during their first 3 months of life, a post hoc secondary analysis of a randomized trial found. Across 11 countries, infants born to mothers assigned to the vaccine arm during pregnancy had a 12.9% (95% CI 1.3-23.1) lower […]
I Hired A Sex Worker To Save My Marriage. Here’s How It Changed Our Lives.
“Do you mind if I touch you?” asked the erotic professional whose sandalwood burning, chakra-chic bedroom I’d recently entered. She was speaking of our general arrangement. We were staring at her bed. In her red wrap-dress, gold sandals and brown bob, she looked like a 50-something starlet from a bygone era. Her current vocation was […]
Astronomers explain origin of elusive ultradiffuse galaxies: How very faint dwarf galaxies are born
As their name suggests, ultradiffuse galaxies, or UDGs, are dwarf galaxies whose stars are spread out over a vast region, resulting in extremely low surface brightness, making them very difficult to detect. Several questions about UDGs remain unanswered: How did these dwarfs end up so extended? Are their dark matter halos — the halos of […]