Treatment De-Escalation Shows Promise in Testicular Cancer
A reduced dose of chemotherapy and involved node radiotherapy (INRT) may be viable for patients with stage IIA or IIB seminoma of the testis, results from a phase II study suggested. In a group of 116 patients, a single-dose of carboplatin along with de-escalated INRT yielded a 3-year progression-free survival (PFS) rate of 93.7% (90% […]
Novel Siderophore Cephalosporin Nets Promising Results in Tough-to-Treat CRAB
WASHINGTON – Cefiderocol (Fetroja) may be a viable targeted-therapy option in critically ill patients with carbapenem-resistant Acinetobacter baumannii infections (CRAB), according to the ongoing PROVE trial. In the real-world setting, patients with CRAB often had multiple comorbidities, including severe burns, which complicates therapy, explained Stephen Marcella, MD, of Shionogi in Florham Park, New Jersey. He […]
Chemo-Free Maintenance Combo Promising in Pancreatic Cancer
Pairing a PARP inhibitor and immune checkpoint inhibitor together may be a viable non-cytotoxic maintenance therapy option for patients with platinum-sensitive pancreatic ductal adenocarcinoma (PDAC), according to findings of a single-center phase Ib/II study. At a median follow-up of 23.0 months, combining the PARP inhibitor niraparib (Zejula) with the anti CTLA-4 antibody ipilimumab (Yervoy) achieved […]