Could Earlier Initiation of HPV Vaccine Boost Immunization in Adolescents?
Teenagers had better vaccine coverage against human papillomavirus (HPV) if they were vaccinated at earlier ages as older children instead of early adolescents, a retrospective study showed. Early initiators vaccinated at age 9 or 10 were, compared with those who initiated at ages 11 to 12, more likely to complete the HPV vaccine series by […]
What Next After Early End of MOSAICO HIV Vaccine Trial?
SEATTLE — The abrupt and early end of the MOSAICO HIV vaccine trial, announced last month, was the topic of a special session at the Conference on Retroviruses and Opportunistic Infections here. Results of the 3,800-participant trial were negative, with an identical 113 individuals in the vaccine regimen and placebo groups becoming infected with HIV […]
Opinion | Should Future COVID Boosters Include the Ancestral Strain?
The current COVID-19 mRNA vaccine boosters are bivalent, meaning they contain equal amounts of spike protein mRNA for the original Wuhan virus sequence and for the BA.4/5 Omicron variants that emerged in mid-2022. How well does this type of bivalent booster perform? The question is relevant because FDA’s recent Vaccines and Related Biological Products Advisory […]
Moderna Booster Vaccine Singled Out for Chronic Hives
The monovalent Moderna COVID-19 booster vaccine may be associated with an elevated risk for new-onset chronic spontaneous urticaria (CSU), or hives lasting more than 6 weeks, according to a Swiss study. Among people who got an mRNA COVID vaccine booster and had new-onset hives reported to local allergists, 90% had vaccination precede CSU in the […]
Zaire Ebola Vaccines Produce Antibody Responses as Early as 14 Days
Three vaccine regimens for Zaire Ebola virus disease (EVD) produced antibody responses in adults and children, according to the results of two randomized trials conducted in West Africa. At 12 months, 41% of adults and 78% of children had a response to the Ad26-MVA regimen (Ad26.ZEBOV followed by MVA-BN-Filo 56 days later), 76% and 87% […]
Yellow Fever Vaccine Potency Wanes Over Time
SEATTLE — A single-dose of vaccine for yellow fever (YF-VAX strain 17D-204) is touted as offering lifelong protection, but the jab’s potency was reduced over time, researchers reported. In blood samples from 22 flavivirus-naïve individuals that were vaccinated for yellow fever within the last 10 years, 9% were 17D seronegative, and almost all (n=21/22) were […]
Vaccine Candidates for RSV Ward Off Severe Illness in Older Adults
WASHINGTON — Prefusion F protein vaccine candidates for respiratory syncytial virus (RSV) proved safe in adults 60 and up while demonstrating an ability to thwart lower respiratory tract illness, including severe cases, a pair of large phase III trials showed. A single dose of an RSV prefusion F protein vaccine (RSVPreF3 OA) yielded a vaccine […]
Extra Hep B Vaccine Dose Exceeds Expectations for People With HIV
WASHINGTON — Three doses of hepatitis B vaccine with a cytosine phosphoguanine adjuvant (HepB-CpG; Heplisav-B) notched a perfect mark when it came to seroprotection for people with HIV who had never before been vaccinated against the hepatitis B virus (HBV), early results of a phase III trial showed. At 28 weeks, the three doses yielded […]
FDA OKs Tdap Vaccine for Whooping Cough Protection Before Birth
The FDA announced approval of the first vaccine to be delivered through a pregnant mother to unborn babies for protection in the first 2 months of life. The tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine Boostrix is to be given during the third trimester of pregnancy to deliver antibodies to the developing […]
CDC: Unvaccinated 14 Times More Likely to Catch Monkeypox
Men eligible for the monkeypox vaccine who did not receive one were roughly 14 times more likely to catch the virus, early real-world effectiveness data from the CDC showed. During the week of August 28, for example, incidence of monkeypox was 230 per 100,000 for those who did not get vaccinated, as compared to 15 […]