Very Early ART Can Result in Sustained HIV Suppression in Neonates
In neonates with acquired in utero HIV infection, administration of antiretroviral therapy (ART) within 48 hours of life can lead to sustained HIV virological suppression by 2 years, a phase I/II proof-of-concept study indicated. In two cohorts who received three-drug nevirapine-based ART regimens within two days of life and maintained protocol- defined virological control criteria […]
Promising Results in First Test of In Utero Enzyme-Replacement Therapy
The first test of in utero enzyme replacement therapy (ERT) proved safe and effective for a baby with infantile-onset Pompe disease, according to a case report. An infant with cross-reactive immunologic material (CRIM)-negative infantile-onset Pompe disease — the most severe end of the disease spectrum — had no cardiac manifestations following treatment, compared to her […]
Some IBD Treatments in Pregnancy Had No Effect on Kids’ Infection Risk
Exposure to immunosuppressive monotherapies in utero did not increase serious infection risks in young children born to mothers with inflammatory bowel disease (IBD), but the same could not be said for exposures to combination therapies, a French population-based study found. Children up to 1 year of age who were exposed to tumor necrosis factor (TNF) […]