Emicizumab Safe, Effective, in Infants With Hemophilia A
SAN DIEGO — Administering emicizumab (Hemlibra) to previously untreated or minimally treated infants with severe hemophilia A without factor VIII inhibitors is effective and safe, according to results from research presented here. The phase III HAVEN-7 study showed that at a median follow-up of 101.9 weeks, the annualized treated bleeding rate was 0.4 (95% CI […]
BRAF-MEK Inhibition Achieves ‘Near Universal’ Response in Rare Brain Tumor
Targeted BRAF-MEK inhibition resulted in a response in nearly all patients with untreated BRAF V600E–mutated papillary craniopharyngioma, according to results from a small phase II study. Of 16 evaluable patients treated with the BRAF inhibitor vemurafenib (Zelboraf) and the MEK inhibitor cobimetinib (Cotellic) over several monthly cycles, 15 had a durable, objective partial response or […]
Durvalumab-CRT Pairing Disappoints in Locally Advanced Cervical Cancer
NEW YORK — An immunotherapy-chemoradiotherapy (CRT) combination did not boost progression-free survival (PFS) in untreated, locally advanced cervical cancer, according to CALLA trial findings. Newly diagnosed patients who received durvalumab (Imfinzi) plus standard CRT did not experience a statistically significant PFS improvement versus patients who received placebo plus CRT (hazard ratio 0.84, 95% CI 0.65-1.08, […]
Non-Chemo Regimen Led to High Response Rates in Cisplatin-Ineligible Bladder Cancer
PARIS — Nearly two-thirds of patients with untreated cisplatin-ineligible advanced urothelial cancer responded to an antibody-drug conjugate (ADC) and immunotherapy, a small randomized study showed. Overall, 49 of 76 patients responded to frontline enfortumab vedotin (EV; Padcev) and pembrolizumab (Keytruda), including eight complete responses. An additional 17 patients had stable disease, resulting in a clinical […]
What Will Happen If H Pylori Goes Untreated? Infection Symptoms
If left untreated H pylori infection can cause abdominal symptoms, as well as lead to the following complications. If left untreated H pylori infection initially can cause abdominal symptoms, such as nausea, vomiting, pain, and diarrhea among others. Long-standing untreated infection can lead to the following complications: Inflammation of the stomach lining. H pylori infection can irritate the […]