Investigational Immunotherapy Combo Shows Promise for Advanced Solid Tumors
An investigational combination of CTLA-4 and PD‐1 checkpoint inhibitors demonstrated “encouraging” tumor activity, as well as a manageable safety profile, in patients with advanced/metastatic solid tumors, according to results from a small phase I study. Among 61 patients with different solid tumors who were evaluated for efficacy, 37.7% achieved an objective response to treatment with […]
Mark Ruffalo Says He Learned Of Brain Tumor From A ‘Crazy’ Dream
LOADINGERROR LOADING Mark Ruffalo vividly remembers learning he had a brain tumor and keeping it from his wife. The “Poor Things” star had only been married to Sunrise Coigney for a year when he found out in June 2001 and revealed Monday on the “Smartless” podcast that he didn’t tell her for two weeks as […]
Mother Speaks Out After College Senior Dies Of Brain Tumor Found On Spring Break
Following a University of Georgia student’s death from a brain tumor found during a spring break vacation, her mother is speaking out about the 21-year-old’s final moments. In an emotional interview published Thursday, Laura McKeithen told People that daughter Liza Burke “lived life” to the fullest despite the tumor, which doctors identified in March after […]
Researchers leverage cell self-destruction to treat brain tumors
Glioblastoma is the most common type of brain tumor in adults. The disease is 100% fatal and there are no cures, making it the most aggressive type of cancer. Such a poor prognosis has motivated researchers and neurosurgeons to understand the biology of tumors with the goal of creating better therapies. Dominique Higgins, MD, PhD, […]
Pre-Op Axitinib Helps for Partial Nephrectomy of Complex Renal Tumors
SAN DIEGO — Use of neoadjuvant axitinib (Inlyta) resulted in significant reductions in tumor size and complexity, enabling partial nephrectomy in a cohort of patients with highly complex renal masses in whom the procedure would ordinarily not be feasible, according to an interim analysis from a small phase II trial. A course of the tyrosine […]
Stress protein in fibroblasts may be a good target for future cancer drugs: ATF4 protein works in tumors and tumor-supporting fibroblasts to promote tumor survival
A stress protein that is overactive in many types of tumor cells also has a key role in tumor-supporting cells called fibroblasts, and may be a good target for future cancer treatments, suggests a study from researchers at the Perelman School of Medicine at the University of Pennsylvania. The researchers, whose findings appear in Nature […]
DNA shed from colon cancers into bloodstream successfully guides chemotherapy after surgery: Helps clarify the benefit of chemotherapy in stage II cancers
A new research study showed that circulating tumor DNA (ctDNA) — genetic material shed from tumors into the bloodstream — can identify stage II colon cancer patients who can most benefit from chemotherapy following surgery and spare other patients the need for this form of treatment. The multi-institutional, international study, led by researchers at the […]
Is Alzheimer’s Risk Lower With TNF Inhibitors?
Tumor necrosis factor (TNF) inhibitors for rheumatoid arthritis were linked with a lower risk of Alzheimer’s disease and related dementia, but only in people with cardiovascular disease, data from the DREAM (Drug Repurposing for Effective Alzheimer’s Medicines) study showed. Among more than 22,000 older adults, targeted disease-modifying antirheumatic drugs overall were not associated with a […]
Chemo Triplet May Boost Survival in Rare Soft-Tissue Sarcoma
Adding temozolomide to a combination of vincristine and irinotecan (VIT) improved tumor response and survival in patients with relapsed or refractory rhabdomyosarcoma in a European phase II trial. In the trial of over 100 patients, the group who received temozolomide had a numerically improved objective response rate (ORR) after two cycles of treatment versus the […]