Sutezolid With 3-Drug Combo Appears Safe and Effective in Multidrug-Resistant TB
SEATTLE — Adding the oxazolidinone antibiotic sutezolid to a three-drug combination appeared to be safe and effective for people with multidrug-resistant tuberculosis (TB), according to a dose-finding phase II study. Across five treatment arms that included four different doses of sutezolid with bedaquiline, delamanid, and moxifloxacin at standard doses, there was a similar increase in […]
Simpler Antifungal Course Works for Cryptococcal Meningitis in Africa
A single high-dose course of liposomal amphotericin B as part of a three-drug antifungal treatment regimen was non-inferior to the current WHO-backed antifungal drug regimen for cryptococcal meningitis in people living with HIV, according to a phase III trial. In an intention-to-treat (ITT) analysis of 814 patients, 101 deaths were reported in the intervention group […]