Bispecific Antibody Shows Promise in R/R Multiple Myeloma
Teclistamab, a bispecific antibody that binds B-cell maturation antigen (BCMA) and CD3 to redirect T cells to multiple myeloma cells, showed promising efficacy in patients with relapsed or refractory disease, according to results from a phase I study. Forty patients received the recommended phase II dose of subcutaneous teclistamab, which led to an overall response […]
We can expect more emissions from oil refineries in the near-term future, analysis finds
A global inventory has revealed that CO2 emissions from oil refineries were 1.3 Gigatonnes (Gt) in 2018 and could be as large as 16.5 Gt from 2020 to 2030. Based on the results, the researchers recommend distinct mitigation strategies for refineries in different regions and age groups. The findings appear August 20 in the journal […]
Rheumatic Events With Checkpoint Inhibitors: Tumor Type Matters
Among the factors that were associated with an increased risk for the development of rheumatic immune-related adverse events following cancer treatment with immune checkpoint inhibitors (ICIs) was the type of malignancy involved, a large case-control study found. Compared with reference lung cancer (the most common type of malignancy in this cohort), the development of a […]
Varying immune cell levels in canine brain tumors could provide therapeutic targets
A new study reveals that high-grade gliomas, or brain tumors, in dogs contained more immune cells associated with suppressing immune response than low-grade gliomas. The work, which is the most extensive examination of immune cell infiltration in canine glioma to date, adds to the body of evidence that these brain tumors might recruit cells that […]
Varying immune cell levels in canine brain tumors could provide therapeutic targets
A new study reveals that high-grade gliomas, or brain tumors, in dogs contained more immune cells associated with suppressing immune response than low-grade gliomas. The work, which is the most extensive examination of immune cell infiltration in canine glioma to date, adds to the body of evidence that these brain tumors might recruit cells that […]
Researchers uncover the biology and treatment behind a rare autoinflammatory disease
The absence of a protein that activates the body’s antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition that is treatable with an FDA-approved class of drugs known as TNF (tumor necrosis factor) inhibitors, a global research team led by Mount Sinai has found. The condition, which is now termed TBK1 deficiency, was previously known […]
How fructose in the diet contributes to obesity
Eating fructose appears to alter cells in the digestive tract in a way that enables it to take in more nutrients, according to a preclinical study from investigators at Weill Cornell Medicine and NewYork-Presbyterian. These changes could help to explain the well-known link between rising fructose consumption around the world and increased rates of obesity […]
What Is Dissociative Amnesia? Causes, Types & Treatment
Dissociative amnesia is a type of mental disorder that can cause varying degrees of memory loss. Learn about causes, types, and treatment Dissociative amnesia is a type of mental disorder that involves a disconnection or disruption of memory, awareness, actions, and identity. People with this type of dissociative disorder may be unable to remember important […]
How microbes can exacerbate cognitive decline
Recent research has found that changes in the gut microbiota — the trillions of bacteria and other microbes that live in the intestines — can alter the brain and behavior. Now, a study led by scientists at UCLA could elucidate how and why that phenomenon occurs. In the experiment, which was conducted with mice, researchers […]
Rebrand of Nurse Anesthetists Met With Criticism From Physician Group
The professional group representing nurse anesthetists announced that it will be known as the American Association of Nurse Anesthesiology (AANA) going forward. But the name change wasn’t met with approval from all sectors of the medical community. The AANA — which represents nearly 60,000 certified registered nurse anesthetists (CRNAs) and student registered nurse anesthetists — […]