FDA Panel Reluctantly Backs Patisiran for ATTR Cardiomyopathy
FDA advisors conceded on Wednesday that the benefit-risk balance of patisiran (Onpattro) technically checks out in wild-type or hereditary transthyretin amyloid cardiomyopathy (ATTR-CM, also known as cardiac ATTR amyloidosis) — though they were unconvinced that the benefits are actually meaningful. At the end of the day, the Cardiovascular and Renal Drugs Advisory Committee ultimately voted […]
Comprehensive insulin signalling map shows interplay between genes and diet
Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a fundamental study of substantial importance. They say the authors share compelling evidence that sheds […]
Both high-protein and normal-protein diets are effective for T2D management
New findings from the University of Alabama at Birmingham indicate that the type of protein in the diet is not as important as the overall amount of weight loss for those with Type 2 diabetes. Published in the journal Obesity, 106 adults with T2D were randomly assigned to either the high-protein or normal-protein diet for […]
Patients With Narcolepsy Face Mood and Pain Disorders
NASHVILLE, Tenn. — People with narcolepsy frequently had mood and pain comorbidities that complicated diagnosis and treatment plans, observational data showed. In a propensity-matched cohort analysis of more than 4,000 individuals, people with narcolepsy were more than twice as likely to be diagnosed with depression (OR 2.11, 95% CI 1.86-2.40, P<0.001) or chronic pain syndrome […]
McConnell’s Medical Report; Mask Mandate War Brews; OTC Naloxone Hits Stores
Note that some links may require registration or subscription. Senate Minority Leader Mitch McConnell (R-Ky.) had no evidence of stroke, seizure disorder, or movement disorder like Parkinson’s disease, Capitol physician Brian Monahan, MD, stated in a letter. (Politico) But Sen. Rand Paul, MD (R-Ky.), an ophthalmologist, thinks differently. (USA Today) Mask on; mask off: President […]
Resistant starch supplement reduces liver triglycerides in people with fatty liver disease
Resistant starch is a nondigestible fiber that ferments in the large intestine, and consumption of it has previously been shown to have a positive effect on metabolism in animal studies. Now, a 4-month randomized controlled trial in people with non-alcoholic fatty liver disease (NAFLD) indicates that daily intake of resistant starch can alter gut bacteria […]
A new breakthrough in obesity research may allow you to lose fat while eating all you want
This is a significant development that brings hope to the one billion individuals with obesity worldwide. Researchers led by Director C. Justin LEE from the Center for Cognition and Sociality (CCS) within the Institute for Basic Science (IBS) have discovered new insights into the regulation of fat metabolism. The focus of their study lies within […]
How a mere 12% of Americans eat half the nation’s beef, creating significant health and environmental impacts
A new study has found that 12% of Americans are responsible for eating half of all beef consumed on a given day, a finding that may help consumer groups and government agencies craft educational messaging around the negative health and environmental impacts of beef consumption. Those 12% — most likely to be men or people […]
This 1 Habit May Help Reduce The Risk Of Dementia In Older Adults
Hinterhaus Productions via Getty Images A new study found that people who took adult education classes have a lower risk of developing dementia. There are certain habits, like exercising and eating nutritious foods, that are synonymous with healthy aging. A new, large-scale study highlights another method that middle-aged and older adults should also add to […]
Deadly Milkshakes; Masks Back at College Campus; Task Force Updates PrEP Guidance
Note that some links may require registration or subscription. Three people died after drinking milkshakes contaminated with listeria at a Frugal’s burger restaurant in Tacoma, Washington. (NBC News) Of course first-year medical residents who started training before the COVID-19 pandemic had lower rates of PTSD symptoms compared with those who started their training during the […]