TULSA Effective in Controlling Prostate Cancer Long-Term
WASHINGTON — Results from a long-term follow-up of the pivotal TACT trial showed that MRI-guided transurethral ultrasound ablation (TULSA) was effective and durable in men with localized prostate cancer. The median prostate-specific antigen (PSA) level at 5 years was 0.63 ng/mL — a 90% reduction from the median PSA at baseline, reported Scott Eggener, MD, […]
Disabled LGBTQ+ Youth At Greater Risk Of Suicide Than Their Peers, Study Finds
A report released this week by a youth suicide prevention group found that young LGBTQ+ people who are disabled have higher rates of mental health issues and are at greater risk of suicide compared to their non-disabled peers. The Trevor Project, a national suicide prevention nonprofit that serves LGBTQ+ youth, surveyed more than 28,500 LGBTQ+ […]
Clinical Challenges: New Hope in Management of Neurofibromatosis
A decade of progress has brought hope to management of genetic tumor-causing conditions that fall under the umbrella of neurofibromatosis (NF). “There have been more discoveries and more approaches in the past decade than the 100 years before that,” said Roger J. Packer, MD, of the Gilbert Family Neurofibromatosis Institute at Children’s National Hospital in […]
Alcohol consumption may have positive and negative effects on cardiovascular disease risk
While past research has indicated that moderate alcohol consumption can lower one’s risk of cardiovascular disease (CVD), more recent studiessuggest that moderate levels of drinking may be hazardous to heart health. A new analysis led by Boston University School of Public Health and Friedman School of Nutrition Science and Policy at Tufts University (Friedman School) […]
Mice eating less of specific amino acid — overrepresented in diet of obese people — live longer, healthier
A new study in mice, published recently in the journal Cell Metabolism, shows that cutting down the amount of a single amino acid called isoleucine can, among other benefits, extend their lifespan, make them leaner and less frail as they age and reduce cancer and prostate problems, all while the mice ate more calories. There’s […]
Mahvash Disease Case Resolved With Liver Transplantation
A woman with Mahvash disease presented with portal hypertension that necessitated liver transplantation; the liver complications observed in this case report distinguish it from what’s more typically seen in patients with this condition. The 27-year-old woman presented with mildly elevated aminotransferase levels and chronic pancreatitis after having experienced three episodes of hematemesis. Although her imaging […]
Mahvash Disease Case Resolved With Liver Transplantation
A woman with Mahvash disease presented with portal hypertension that necessitated liver transplantation; the liver complications observed in this case report distinguish it from what’s more typically seen in patients with this condition. The 27-year-old woman presented with mildly elevated aminotransferase levels and chronic pancreatitis after having experienced three episodes of hematemesis. Although her imaging […]
Feeding dogs raw meat increases the risk of antibiotic-resistant E. coli
Feeding dogs raw (uncooked) meat increases their risk of excreting E. coli that cannot be killed by a widely used antibiotic — ciprofloxacin — researchers at the University of Bristol have found from a study of 600 healthy pet dogs. E. coli, which can cause food poisoning, is also the UK’s most common cause of […]
Drug Candidate for Chronic Cough Rejected by FDA Panel
FDA advisors told the agency that the current evidence does not support approval of gefapixant for chronic cough, a condition where no approved therapy exists. On Friday, members of the Pulmonary-Allergy Drugs Advisory Committee voted 12-1 that the small reductions in cough frequency demonstrated in phase III trials of the P2X3 receptor antagonist do not […]
Novel Gout Drug Aces Mid-Stage Tests
SAN DIEGO — An investigational once-daily oral agent that inhibits urate transporter-1 (URAT1) as a means of forcing uric acid excretion showed good efficacy and safety in a pair of phase II trials reported here. In one of these studies, the new product, called AR882 for the time being, reduced serum urate by 40% to […]